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. 1970 Jul;49(7):1311–1315. doi: 10.1172/JCI106346

Observations on a model of proliferative lung disease

II. Description of pulmonary gas exchange and comparison of Fick and dye cardiac outputs

P R B Caldwell 1, U Echeverri 1, M M Kilcoyne 1, H W Fritts Jr 1
PMCID: PMC322602  PMID: 4914677

Abstract

Measurements of gas exchange in dogs with granulomatous lung disease resembled those which have been made in similar disorders of man. The minute volume of ventilation was large, the oxygen extracted from each liter of ventilation was low, and the arterial blood oxygen saturation tended to be subnormal despite hyperventilation. When the diseased dogs breathed 21% oxygen and had alveolar oxygen tensions above 100 mm Hg, the pulmonary blood flows calculated from the Fick principle were significantly higher than those estimated by the dye-dilution method. By way of contrast, the two values agreed when the alveolar tensions were lowered. Whether the agreement of the flows is causally related to the alveolar tension remains an open question. A possible explanation may lie in the effect of alveolar tension on the oxygen consumed by the diseased lung.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEICKERT A., BRAUN W. Das Verhalten der Milchsäure in der menschlichen Lunge bei Luft- und Sauerstoffatmung. Klin Wochenschr. 1956 Mar 1;34(9-10):246–248. doi: 10.1007/BF01481657. [DOI] [PubMed] [Google Scholar]
  2. EISFELD G., JULICH H. Das Verhalten des Milchsäure-, Brenztraubensäuresowie Zitronensäurespiegels im Lungenkreislauf. Z Kreislaufforsch. 1956 Nov;45(21-22):874–880. [PubMed] [Google Scholar]
  3. FRITTS H. W., Jr, RICHARDS D. W., COURNAND A. Oxygen consumption of tissues in the human lung. Science. 1961 Apr 7;133(3458):1070–1072. doi: 10.1126/science.133.3458.1070. [DOI] [PubMed] [Google Scholar]
  4. HALMAGYI D., REINBOLD A., FELKAI B., IVANYI J. Zur Frage der intrapulmonalen Milchsäureoxydation beim Menschen. Klin Wochenschr. 1951 Mar 15;29(11-12):219–220. doi: 10.1007/BF01480002. [DOI] [PubMed] [Google Scholar]
  5. HARRIS P., BAILEY T., BATEMAN M., FITZGERALD M. G., GLOSTER J., HARRIS E. A., DONALD K. W. LACTATE, PYRUVATE, GLUCOSE, AND FREE FATTY ACID IN MIXED VENOUS AND ARTERIAL BLOOD. J Appl Physiol. 1963 Sep;18:933–936. doi: 10.1152/jappl.1963.18.5.933. [DOI] [PubMed] [Google Scholar]
  6. MITCHELL A. M., COURNAND A. The fate of circulating lactic acid in the human lung. J Clin Invest. 1955 Mar;34(3):471–476. doi: 10.1172/JCI103096. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. STRAUSS B. IN VITRO RESPIRATION OF NORMAL AND PATHOLOGIC HUMAN LUNG. J Appl Physiol. 1964 May;19:503–509. doi: 10.1152/jappl.1964.19.3.503. [DOI] [PubMed] [Google Scholar]
  8. Strauss B., Caldwell P. R., Fritts H. W., Jr Observations on a model of prolifer- ative lung disease. I. Transpulmonary arteriovenous differences of lactate, pyruvate, and glucose. J Clin Invest. 1970 Jul;49(7):1305–1310. doi: 10.1172/JCI106345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. THEYE R. A., REHDER K., QUESADA R. S., FOWLER W. S. MEASUREMENT OF CARDIAC OUTPUT BY AN INDICATOR-DILUTION METHOD. Anesthesiology. 1964 Jan-Feb;25:71–74. doi: 10.1097/00000542-196401000-00012. [DOI] [PubMed] [Google Scholar]

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