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. 1970 Jul;49(7):1349–1356. doi: 10.1172/JCI106351

The effect of cardiac disease on hemoglobin-oxygen binding

R D Woodson 1,2, J D Torrance 1,2, S D Shappell 1,2, C Lenfant 1,2
PMCID: PMC322607  PMID: 5432370

Abstract

The relation between degree of cardiac functional impairment and changes in hemoglobin-oxygen affinity and 2,3-diphosphoglycerate (2,3-DPG) has been studied in 39 patients with noncyanotic heart disease. A progressive decline in hemoglobin-oxygen affinity was found with worsening cardiac function as assessed by cardiac index, arteriovenous oxygen (A-V O2) difference, and cardiac symptoms; this alteration in hemoglobin-oxygen binding represents a significant mechanism for adaptation to the limited oxygen supply imposed by the cardiac lesion. The highly significant correlation of mixed venous blood oxygen saturation (S[unk]VVO2) with 2,3-DPG and the position of the oxygen dissociation curve suggests that the level of deoxygenated hemoglobin is an important in vivo regulator of hemoglobin-oxygen affinity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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