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. 1970 Jul;49(7):1357–1367. doi: 10.1172/JCI106352

Antithyroid effects of lithium

S C Berens 1, R S Bernstein 1, J Robbins 1, J Wolff 1
PMCID: PMC322608  PMID: 4194189

Abstract

Lithium has been reported to be goitrogenic when used for the treatment of manic-depressive psychosis. To investigate the effects of lithium on iodine metabolism, male Sprague-Dawley rats were placed on a low iodine (LID) or normal iodine diet (NID) containing enough Li2CO3 to give serum lithium levels of 0.23-0.86 mEq/liter (human therapeutic range is 0.6-1.6 mEq/liter). The following effects were noted with lithium treatment: (a) thyroid weight increased concomitant with a slowing of thyroidal iodine release; (b) the ability to concentrate iodide was increased only after goiters were established; (c) on the LID, 131I uptake was elevated throughout all phases of treatment, even when the release rate was normal; (d) iodine organification was unaffected but the proportion of 131I present as iodothyronines was decreased; (e) the thyroidal 127I content was increased; (f) despite these changes, the serum PBI remained normal as did the thyroxine turnover rate; and (g) thyrotropin (TSH) levels in serum were the same as controls except for a slight elevation early in the course of treatment; TSH levels did not correlate with goitrogenesis.

When LiCl was injected in large doses into intact rats (giving serum lithium levels of 3.08-3.89 mEq/liter), the iodide concentrating mechanism, 131I uptake, and 131I release rates were depressed. Similar experiments in hypophysectomized rats receiving TSH demonstrated these to be local antithyroid effects not mediated through the pituitary.

The discrepancy between acute and chronic responses to lithium, and the dissociation between the inhibition of iodine release and stimulatory effects is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENOTTI J., BENOTTI N. PROTEIN-BOUND IODINE, TOTAL IODINE, AND BUTANOL-EXTRACTABLE IODINE BY PARTIAL AUTOMATION. Clin Chem. 1963 Aug;12:408–416. [PubMed] [Google Scholar]
  2. Benotti J., Benotti N., Pino S., Gardyna H. Determination of total iodine in urine, stool, diets, and tissue. Clin Chem. 1965 Oct;11(10):932–936. [PubMed] [Google Scholar]
  3. Bray G. A. Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin. J Clin Invest. 1968 Jul;47(7):1640–1647. doi: 10.1172/JCI105855. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cooper T. B., Simpson G. M. Preliminary report of a longitudinal study of the effects of lithium on iodine metabolism. Curr Ther Res Clin Exp. 1969 Oct;11(10):603–608. [PubMed] [Google Scholar]
  5. HALMI N. S., SPIRTOS B. N., BOGDANOVE E. M., LIPNER H. J. A study of various influences on the iodide concentrating mechanism of the rat thyroid. Endocrinology. 1953 Jan;52(1):19–32. doi: 10.1210/endo-52-1-19. [DOI] [PubMed] [Google Scholar]
  6. Inoue K., Taurog A. Digestion of 131I-labeled thyroid tissue with maximum recovery of 131I-iodothyronines. Endocrinology. 1967 Aug;81(2):319–332. doi: 10.1210/endo-81-2-319. [DOI] [PubMed] [Google Scholar]
  7. NAGATAKI S., SHIZUME K., OKINAKA S. Effect of thyrotrophin on the metabolism of iodide-131 in the thyroid gland. Endocrinology. 1961 Aug;69:199–209. doi: 10.1210/endo-69-2-199. [DOI] [PubMed] [Google Scholar]
  8. Schou M., Amdisen A., Eskjaer Jensen S., Olsen T. Occurrence of goitre during lithium treatment. Br Med J. 1968 Sep 21;3(5620):710–713. doi: 10.1136/bmj.3.5620.710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Schou M. Lithium in psychiatric therapy and prophylaxis. J Psychiatr Res. 1968 Jun;6(1):67–95. doi: 10.1016/0022-3956(68)90047-2. [DOI] [PubMed] [Google Scholar]
  10. WOLFF J. Some factors that influence the release of iodine from the thyroid gland. Endocrinology. 1951 Mar;48(3):284–297. doi: 10.1210/endo-48-3-284. [DOI] [PubMed] [Google Scholar]
  11. Wilber J. F., Utiger R. D. Immunoassay studies of thyrotropin in rat pituitary glands and serum. Endocrinology. 1967 Jul;81(1):145–151. doi: 10.1210/endo-81-1-145. [DOI] [PubMed] [Google Scholar]
  12. Wolff J., Berens S. C., Jones A. B. Inhibition of thyrotropin-stimulated adenyl cyclase activity of beef thyroid membranes by low concentration of lithium ion. Biochem Biophys Res Commun. 1970 Apr 8;39(1):77–82. doi: 10.1016/0006-291x(70)90760-6. [DOI] [PubMed] [Google Scholar]

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