Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1970 Sep;49(9):1679–1684. doi: 10.1172/JCI106385

The effect of hydrocortisone on immunoglobulin metabolism

Arthur L Levy 1, Thomas A Waldmann 1
PMCID: PMC322651  PMID: 4194767

Abstract

The serum concentration of all subclasses of IgG (γ2A, γ2B, and γ1) as well as IgA and IgM were reduced in normal and low pathogen mice receiving hydrocortisone acetate. Turnover studies using 131I-labeled γ2A subclass of IgG demonstrated that high dose corticosteroids cause a significantly shortened survival (increased catabolic rate) which contributes to the observed hypogammaglobulinemia. This increase in fractional catabolism is not due to excess loss in the urine or stool but reflects an increase in endogenous catabolism.

Full text

PDF
1679

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BJØRNEBOE M., FISCHEL E. E., STOERK H. C. The effect of cortisone and adrenocorticotrophic hormone on the concentration of circulating antibody. J Exp Med. 1951 Jan;93(1):37–48. doi: 10.1084/jem.93.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DIXON F. J., TALMAGE D. W., MAURER P. H., DEICHMILLER M. The half-life on homologous gamma globulin (antibody) in several species. J Exp Med. 1952 May;95(5):313–318. doi: 10.1084/jem.96.4.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
  4. FAHEY J. L., SELL S. THE IMMUNOGLOBULINS OF MICE. V. THE METABOLIC (CATABOLIC) PROPERTIES OF FIVE IMMUNOGLOBULIN CLASSES. J Exp Med. 1965 Jul 1;122:41–58. doi: 10.1084/jem.122.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FARTHING C. P., GERWING J., SHEWELL J. The catabolism of 131I-labelled homologous gamma-globulin in normal, hyperthyroid and hypothyroid rats. J Endocrinol. 1960 Sep;21:83–89. doi: 10.1677/joe.0.0210083. [DOI] [PubMed] [Google Scholar]
  6. FISCHEL E. E., STOERK H. C., BJØRNEBOE M. Failure of cortisone to affect rate of disappearance of antibody protein. Proc Soc Exp Biol Med. 1951 May;77(1):111–114. doi: 10.3181/00379727-77-18695. [DOI] [PubMed] [Google Scholar]
  7. FLICK A. L., STEINFELD J. L. The effect of fever and corticotropin on the in vivo degradation of albumin in man as measured with iodinated human serum albumin. Am J Med Sci. 1958 Jul;236(1):65–80. doi: 10.1097/00000441-195807000-00009. [DOI] [PubMed] [Google Scholar]
  8. GERMUTH F. G., Jr, OYAMA J., OTTINGER B. The mechanism of action of 17-hydroxy-11-dehydrocorticosterone (compound E) and of the adrenocorticotropic hormone in experimental hypersensitivity in rabbits. J Exp Med. 1951 Aug;94(2):139–170. doi: 10.1084/jem.94.2.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. JAGER B. V., BROWN H., NICKERSON M. Alterations in plasma proteins, plasma volume, and volume of packed red cells in patients receiving ACTH or cortisone. J Lab Clin Med. 1951 Mar;37(3):431–443. [PubMed] [Google Scholar]
  10. MATTHEWS C. M. The theory of tracer experiments with 131I-labelled plasma proteins. Phys Med Biol. 1957 Jul;2(1):36–53. doi: 10.1088/0031-9155/2/1/305. [DOI] [PubMed] [Google Scholar]
  11. Peraino C. Regulatory effects of glucocorticoids on ornithine aminotransferase and serine dehydratase in rat liver. Biochim Biophys Acta. 1968 Aug 6;165(1):108–112. doi: 10.1016/0304-4165(68)90194-3. [DOI] [PubMed] [Google Scholar]
  12. ROTHSCHILD M. A., SCHREIBER S. S., ORATZ M., McGEE H. L. The effects of adrenocortical hormones on albumin metabolism studied with albumin-I 131. J Clin Invest. 1958 Sep;37(9):1229–1235. doi: 10.1172/JCI103711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. SELL S. EVIDENCE FOR SPECIES' DIFFERENCES IN THE EFFECT OF SERUM GAMMA-GLOBULIN CONCENTRATION ON GAMMA-GLOBULIN CATABOLISM. J Exp Med. 1964 Nov 1;120:967–986. doi: 10.1084/jem.120.5.967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Schimke R. T. Protein turnover and the regulation of enzyme levels in rat liver. Natl Cancer Inst Monogr. 1967 Nov;27:301–314. [PubMed] [Google Scholar]
  15. Watanabe M., Potter V. R., Pitot H. C. Systematic oscillations in tyrosine transaminase and other metabolic functions in liver of normal and adrenalectomized rats on controlled feeding schedules. J Nutr. 1968 Jun;95(2):207–227. doi: 10.1093/jn/95.2.207. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES