Table 2.
Common and Important CYP2D6 Polymorphisms
| CYP2D6 Allele/Haplotype |
Nucleotide Change | Metabolizer Class |
Caucasians | African- Americans |
|---|---|---|---|---|
| *1 | reference | EM (wild-type) | 0.33 – 0.36 | 0.29 – 0.35 |
| *2 | 2850C>T, 4180G>C | EM | 0.22 – 0.33 | 0.18 – 0.27 |
| *3 | 2549delA | PM | 0.01 – 0.04 | 0 |
| *4 | 1846G>A | PM | 0.12 – 0.21 | 0.06 – 0.08 |
| *5 | CYP2D6 deleted | PM | 0.02 – 0.07 | 0.06 – 0.07 |
| *6 | 1707delT | PM | 0.01 | 0 |
| *9 | 2615–2617delAAG | IM | 0 – 0.02 | 0 |
| *10 | 100C>T | IM | 0.01 – 0.02 | 0.03 – 0.08 |
| *17 | 1023C>T, 2850C>T | IM | 0 | 0.15 – 0.23 |
| *29 | 1659G>A; 1661G>C; 2850C>T; 3183G>A; 4180G>C | IM | N/D | N/D |
| *41 | 2988G>A | IM | N/D | N/D |
| UM | Multiple copies | UM | 0.02 | 0.01 – 0.05 |
EM = extensive metabolizer; IM = intermediate metabolizer; PM = poor metabolizer; UM = ultrarapid metabolizer.