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. Author manuscript; available in PMC: 2011 Nov 30.
Published in final edited form as: Biochemistry. 2007 Dec 23;47(3):986–996. doi: 10.1021/bi7021624

Figure 4.

Figure 4

Mero-S100A4 does not regulate the monomer–polymer equilibrium of myosin-IIA filaments. (A) Promotion of myosin-IIA filament disassembly by wild-type and Mero-S100A4. At a ratio of one wild-type S100A4 dimer per myosin-IIA rod, most of the myosin-IIA rods are present in the supernatant. A ratio of five Mero-S100A4 dimers per myosin-IIA rod has no effect on the myosin-IIA filaments. (B) Inhibition of myosin-IIA filament assembly by wild-type and Mero-S100A4. At a ratio of one S100A4 dimer per myosin-IIA rod, wild-type S100A4 inhibits the assembly of myosin-IIA monomers into filaments. Mero-S100A4 does not inhibit the assembly of the myosin-IIA rods at a ratio of five Mero-S100A4 dimers per myosin-IIA rod.