Figure 1.

Simplified diagram of signaling cascades downstream of FLT3 that are thought to promote leukemogenesis.

Abbreviations: BAD, Bcl-2-associated death promoter; ERK, extracellular signal–related kinase; FL, FLT3 ligand; FLT3, FMS-like tyrosine kinase 3; Grb2, growth factor receptor-bound protein 2; MEK, mitogen-activated protein kinase/ERK kinase; mTOR, mammalian target of rapamycin; PI3K, phosphoinositide 3-kinase; PIM1, proto-oncogene serine/threonine-protein kinase 1; PIP₂, phosphatidylinositol-bisphosphate; PIP₃, phosphatidylinositol-trisphosphate; Rheb, Ras homolog enriched in brain; SOS, son of sevenless; STAT-5, signal transducer and activator of transcription 5; TSC, tuberous sclerosis protein.

Figure derived from one obtained courtesy of Dr. Mark Levis, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins, Baltimore, MD.