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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1986 Feb;83(3):740–741. doi: 10.1073/pnas.83.3.740

Influence of a genetic difference confined to mutation of H-2K on the incidence of pregnancy block in mice.

K Yamazaki, G K Beauchamp, O Matsuzaki, D Kupniewski, J Bard, L Thomas, E A Boyse
PMCID: PMC322940  PMID: 3456167

Abstract

In mice, pregnancy is often terminated when the stud male is removed and the pregnant female is exposed to the presence or scent of an unfamiliar male. It is reported here that the incidence of such blocking of pregnancy was higher when the stud and unfamiliar male differed by mutation of the H-2K class I gene of the major histocompatibility complex than when the stud and unfamiliar males were genetically identical. Thus, the olfactory distinction of mice differing by mutation of the H-2K gene, previously demonstrated after training of mice in a Y maze, can spontaneously influence neuroendocrine communications affecting reproduction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beauchamp G. K., Yamazaki K., Wysocki C. J., Slotnick B. M., Thomas L., Boyse E. A. Chemosensory recognition of mouse major histocompatibility types by another species. Proc Natl Acad Sci U S A. 1985 Jun;82(12):4186–4188. doi: 10.1073/pnas.82.12.4186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ryan K. D., Schwartz N. B. Changes in serum hormone levels associated with male-induced ovulation in group-housed adult female mice. Endocrinology. 1980 Mar;106(3):959–966. doi: 10.1210/endo-106-3-959. [DOI] [PubMed] [Google Scholar]
  3. Schulze D. H., Pease L. R., Geier S. S., Reyes A. A., Sarmiento L. A., Wallace R. B., Nathenson S. G. Comparison of the cloned H-2Kbm1 variant gene with the H-2Kb gene shows a cluster of seven nucleotide differences. Proc Natl Acad Sci U S A. 1983 Apr;80(7):2007–2011. doi: 10.1073/pnas.80.7.2007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Weiss E. H., Mellor A., Golden L., Fahrner K., Simpson E., Hurst J., Flavell R. A. The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events. Nature. 1983 Feb 24;301(5902):671–674. doi: 10.1038/301671a0. [DOI] [PubMed] [Google Scholar]
  5. Yamazaki K., Beauchamp G. K., Bard J., Thomas L., Boyse E. A. Chemosensory recognition of phenotypes determined by the Tla and H-2K regions of chromosome 17 of the mouse. Proc Natl Acad Sci U S A. 1982 Dec;79(24):7828–7831. doi: 10.1073/pnas.79.24.7828. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Yamazaki K., Beauchamp G. K., Egorov I. K., Bard J., Thomas L., Boyse E. A. Sensory distinction between H-2b and H-2bm1 mutant mice. Proc Natl Acad Sci U S A. 1983 Sep;80(18):5685–5688. doi: 10.1073/pnas.80.18.5685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Yamazaki K., Beauchamp G. K., Thomas L., Boyse E. A. Chemosensory identity of H-2 heterozygotes. J Mol Cell Immunol. 1984;1(2):79–82. [PubMed] [Google Scholar]
  8. Yamazaki K., Beauchamp G. K., Wysocki C. J., Bard J., Thomas L., Boyse E. A. Recognition of H-2 types in relation to the blocking of pregnancy in mice. Science. 1983 Jul 8;221(4606):186–188. doi: 10.1126/science.6857281. [DOI] [PubMed] [Google Scholar]
  9. Yamazaki K., Boyse E. A., Miké V., Thaler H. T., Mathieson B. J., Abbott J., Boyse J., Zayas Z. A., Thomas L. Control of mating preferences in mice by genes in the major histocompatibility complex. J Exp Med. 1976 Nov 2;144(5):1324–1335. doi: 10.1084/jem.144.5.1324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Yamazaki K., Yamaguchi M., Baranoski L., Bard J., Boyse E. A., Thomas L. Recognition among mice. Evidence from the use of a Y-maze differentially scented by congenic mice of different major histocompatibility types. J Exp Med. 1979 Oct 1;150(4):755–760. doi: 10.1084/jem.150.4.755. [DOI] [PMC free article] [PubMed] [Google Scholar]

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