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. 1986 Mar;83(6):1886–1890. doi: 10.1073/pnas.83.6.1886

Autocrine growth inhibition of a cloned line of helper T cells.

J B Horowitz, J Kaye, P J Conrad, M E Katz, C A Janeway Jr
PMCID: PMC323189  PMID: 2937064

Abstract

The growth of T lymphocytes is dependent on the T-cell growth factor interleukin 2 (IL-2), which causes T cells bearing high-affinity receptors for IL-2 to proliferate. Most cloned helper-T-cell lines can be shown to both produce and respond to IL-2; thus, growth of such cells is by an autocrine mechanism. We report that the failure of the cloned murine T-cell line D10.G4.1 to respond to its own IL-2 results from the secretion, by the same cells, of a potent inhibitor of the IL-2-driven T-cell proliferative response. This inhibition can be overcome by increasing the number of IL-2 receptors expressed by the target cell. In the cloned T-cell line producing the inhibitory substance, this increase in IL-2 receptors is driven by the monokine interleukin-1. We propose that this inhibitor of IL-2 responses may play a role in preventing "bystander" activation of T cells by IL-2 released in vivo and could be a potent pharmacologic agent.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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