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. 1986 Apr;83(7):1965–1969. doi: 10.1073/pnas.83.7.1965

A preliminary three-dimensional structure of angiogenin.

K A Palmer, H A Scheraga, J F Riordan, B L Vallee
PMCID: PMC323210  PMID: 3457369

Abstract

A preliminary three-dimensional structure of angiogenin has been computed, based on its homology to bovine pancreatic ribonuclease A. A standard-geometry structure of ribonuclease was first obtained from its x-ray coordinates. The fit of the backbone of angiogenin to that of ribonuclease was then optimized by taking account of amino acid deletions and by minimizing its conformational energy-plus-a-penalty distance function constraining its backbone to that of ribonuclease. Side-chain and backbone dihedral angles were allowed to vary throughout the cycles of energy minimization. In the last stages of minimization, the penalty distance function was removed. A low-energy structure resembling ribonuclease was obtained.

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1965

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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