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. 1986 Apr;83(8):2345–2349. doi: 10.1073/pnas.83.8.2345

A molecular mechanism for sensory adaptation based on ligand-induced receptor modification.

B E Knox, P N Devreotes, A Goldbeter, L A Segel
PMCID: PMC323293  PMID: 3010308

Abstract

Physiological responses mediated by cell-surface receptors frequently adapt or "desensitize" (i.e., terminate despite persistent occupancy of receptors by ligand). Binding of ligands to the external domains of a wide variety of surface receptors induces covalent modification of their cytoplasmic domains. A mechanism is presented in which the variety of receptor states generated by ligand binding and covalent modification act together to regulate physiological responsiveness. The development of the model is guided by observations of adaptation for chemotaxis in Escherichia coli and adenylate cyclase activation in Dictyostelium. The general features of the marked response and eventual exact adaptation predicted by the model match those observed in the experimental systems.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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