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. 1986 Apr;83(8):2350–2352. doi: 10.1073/pnas.83.8.2350

Alteration of adenyl dinucleotide metabolism by environmental stress.

J C Baker, M K Jacobson
PMCID: PMC323294  PMID: 3458199

Abstract

Exposure of cultured mammalian cells to a variety of conditions that induce the synthesis of stress proteins, including hyperthermia, ethanol, cadmium, and arsenite resulted in an increased cellular content of adenyl dinucleotides including diadenosine tetraphosphate (Ap4A). Exposure to other agents that cause metabolic perturbations not known to induce the synthesis of stress proteins, such as cyclohexamide, cytosine arabinoside, hydroxyurea, and ultraviolet irradiation did not alter the content of these nucleotides. It is proposed that these unique nucleotides may mediate adaptive responses of mammalian cells to environmental stress.

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Selected References

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