Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1986 Apr;83(8):2443–2447. doi: 10.1073/pnas.83.8.2443

Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes.

F Malavasi, C Tetta, A Funaro, G Bellone, E Ferrero, A C Franzone, P Dellabona, R Rusci, L Matera, G Camussi, et al.
PMCID: PMC323314  PMID: 3085094

Abstract

Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.

Full text

PDF
2443

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benveniste J., Le Couedic J. P., Polonsky J., Tence M. Structural analysis of purified platelet-activating factor by lipases. Nature. 1977 Sep 8;269(5624):170–171. doi: 10.1038/269170a0. [DOI] [PubMed] [Google Scholar]
  2. Biron C. A., Turgiss L. R., Welsh R. M. Increase in NK cell number and turnover rate during acute viral infection. J Immunol. 1983 Sep;131(3):1539–1545. [PubMed] [Google Scholar]
  3. Blank M. L., Snyder F. Improved high-performance liquid chromatographic method for isolation of platelet-activating factor from other phospholipids. J Chromatogr. 1983 Apr 8;273(2):415–420. doi: 10.1016/s0378-4347(00)80963-9. [DOI] [PubMed] [Google Scholar]
  4. Camussi G., Aglietta M., Coda R., Bussolino F., Piacibello W., Tetta C. Release of platelet-activating factor (PAF) and histamine. II. The cellular origin of human PAF: monocytes, polymorphonuclear neutrophils and basophils. Immunology. 1981 Feb;42(2):191–199. [PMC free article] [PubMed] [Google Scholar]
  5. Camussi G., Aglietta M., Malavasi F., Tetta C., Piacibello W., Sanavio F., Bussolino F. The release of platelet-activating factor from human endothelial cells in culture. J Immunol. 1983 Nov;131(5):2397–2403. [PubMed] [Google Scholar]
  6. Camussi G., Bussolino F., Tetta C., Piacibello W., Aglietta M. Biosynthesis and release of platelet-activating factor from human monocytes. Int Arch Allergy Appl Immunol. 1983 Mar;70(3):245–251. doi: 10.1159/000233331. [DOI] [PubMed] [Google Scholar]
  7. Goldman D. W., Goetzl E. J. Specific binding of leukotriene B4 to receptors on human polymorphonuclear leukocytes. J Immunol. 1982 Oct;129(4):1600–1604. [PubMed] [Google Scholar]
  8. Griffin J. D., Hercend T., Beveridge R., Schlossman S. F. Characterization of an antigen expressed by human natural killer cells. J Immunol. 1983 Jun;130(6):2947–2951. [PubMed] [Google Scholar]
  9. Henson P. M. Activation of rabbit platelets by platelet-activating factor derived from IgE-sensitized basophils. Characteristics of the aggregation and its dissociation from secretion. J Clin Invest. 1977 Aug;60(2):481–490. doi: 10.1172/JCI108799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hoffman D. R., Hajdu J., Snyder F. Cytotoxicity of platelet activating factor and related alkyl-phospholipid analogs in human leukemia cells, polymorphonuclear neutrophils, and skin fibroblasts. Blood. 1984 Mar;63(3):545–552. [PubMed] [Google Scholar]
  11. London L., Perussia B., Trinchieri G. Induction of proliferation in vitro of resting human natural killer cells: expression of surface activation antigens. J Immunol. 1985 Feb;134(2):718–727. [PubMed] [Google Scholar]
  12. Malavasi F., Bellone G., Matera L., Milanese C., Ferrero E., Funaro A., Demaria S., Caligaris-Cappio F., Camussi G., Dellabona P. Murine monoclonal antibodies as probes for the phenotypical, functional, and molecular analysis of a discrete peripheral blood lymphocyte population exerting natural killer activity in vitro. Hum Immunol. 1985 Oct;14(2):87–102. doi: 10.1016/0198-8859(85)90067-9. [DOI] [PubMed] [Google Scholar]
  13. Malavasi F., Caligaris-Cappio F., Milanese C., Dellabona P., Richiardi P., Carbonara A. O. Characterization of a murine monoclonal antibody specific for human early lymphohemopoietic cells. Hum Immunol. 1984 Jan;9(1):9–20. doi: 10.1016/0198-8859(84)90003-x. [DOI] [PubMed] [Google Scholar]
  14. Malavasi F., Funaro A., Bellone G., Caligaris-Cappio F., Berti E., Tetta C., Dellabona P., DeMaria S., Campogrande M., Cappa A. P. Functional and molecular characterization by the CB04 monoclonal antibody of a cell surface structure exerting C3-complement receptor activity. J Clin Immunol. 1985 Nov;5(6):412–420. doi: 10.1007/BF00915339. [DOI] [PubMed] [Google Scholar]
  15. Malavasi F., Milanese C., Fabbi M., Richiardi P., Caligaris-Cappio F., Ferrero E., Roggero S., Dellabona P., Ceppellini R. Generation and characterization of murine monoclonal antibodies against HLA Class II molecules. Diagn Immunol. 1984;2(1):53–62. [PubMed] [Google Scholar]
  16. Perussia B., Trinchieri G., Jackson A., Warner N. L., Faust J., Rumpold H., Kraft D., Lanier L. L. The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies. J Immunol. 1984 Jul;133(1):180–189. [PubMed] [Google Scholar]
  17. Phillips J. H., Le A. M., Lanier L. L. Natural killer cells activated in a human mixed lymphocyte response culture identified by expression of Leu-11 and class II histocompatibility antigens. J Exp Med. 1984 Apr 1;159(4):993–1008. doi: 10.1084/jem.159.4.993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Pinckard R. N., Farr R. S., Hanahan D. J. Physicochemical and functional identity of rabbit platelet-activating factor (PAF) released in vivo during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils. J Immunol. 1979 Oct;123(4):1847–1857. [PubMed] [Google Scholar]
  19. Pohajdak B., Gomez J. L., Wilkins J. A., Greenberg A. H. Tumor-activated NK cells trigger monocyte oxidative metabolism. J Immunol. 1984 Nov;133(5):2430–2436. [PubMed] [Google Scholar]
  20. Rossi P., Lindgren J. A., Kullman C., Jondal M. Products of the lipoxygenase pathway in human natural killer cell cytotoxicity. Cell Immunol. 1985 Jun;93(1):1–8. doi: 10.1016/0008-8749(85)90383-1. [DOI] [PubMed] [Google Scholar]
  21. Scala G., Allavena P., Djeu J. Y., Kasahara T., Ortaldo J. R., Herberman R. B., Oppenheim J. J. Human large granular lymphocytes are potent producers of interleukin-1. Nature. 1984 May 3;309(5963):56–59. doi: 10.1038/309056a0. [DOI] [PubMed] [Google Scholar]
  22. Steinhauer E. H., Doyle A. T., Kadish A. S. Human natural killer cytotoxic factor (NKCF): role of IFN-alpha. J Immunol. 1985 Jul;135(1):294–299. [PubMed] [Google Scholar]
  23. Timonen T., Ortaldo J. R., Stadler B. M., Bonnard G. D., Sharrow S. O., Herberman R. B. Cultures of purified human natural killer cells: growth in the presence of interleukin 2. Cell Immunol. 1982 Sep 1;72(1):178–185. doi: 10.1016/0008-8749(82)90295-7. [DOI] [PubMed] [Google Scholar]
  24. Trinchieri G., Perussia B. Human natural killer cells: biologic and pathologic aspects. Lab Invest. 1984 May;50(5):489–513. [PubMed] [Google Scholar]
  25. Ziegler A., Uchańska-Ziegler B., Zeuthen J., Wernet P. HLA antigen expression at the single cell level on a K562 X B cell hybrid: an analysis with monoclonal antibodies using bacterial binding assays. Somatic Cell Genet. 1982 Nov;8(6):775–789. doi: 10.1007/BF01543018. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES