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. 1986 May;83(9):3032–3036. doi: 10.1073/pnas.83.9.3032

Relationship between transmitter release and presynaptic calcium influx when calcium enters through discrete channels.

R S Zucker, A L Fogelson
PMCID: PMC323441  PMID: 2422666

Abstract

We have used a three-dimensional diffusion model of calcium entering the presynaptic nerve terminal through discrete channels to simulate experiments relating transmitter release to presynaptic calcium current. The relationship will be less than linear, or will curve downward, if calcium channels are well separated. It will resemble a power-law function with exponent less than the cooperativity of calcium action if channels are clustered closer together. Large presynaptic depolarizations elicit more release than small depolarizations admitting the same calcium influx. This occurs because large pulses open more channels near each other, with the result that the calcium concentration near release sites is greater, due to overlap of calcium diffusing from adjacent channels.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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