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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1986 May;83(10):3412–3416. doi: 10.1073/pnas.83.10.3412

T cells can be cytotoxic without making interleukin 2: a model of separate pathways of induction.

D Bellgrau, D W Talmage
PMCID: PMC323524  PMID: 2939451

Abstract

The thoracic duct lymphocytes from rats previously injected with ultraviolet-light-irradiated allogeneic lymphocytes were grown for 4 days with alloantigen, with or without Con A-induced lymphokine factors, and then for 3 days with the lymphokines alone. They were then tested for their cytoxicity and for their capacity to make interleukin 2 (IL-2) in response to antigen. The results show that T helper cells specific for both class I and class II antigens of the major histocompatibility complex were removed from the circulation by the injection of ultraviolet-irradiated alloantigen. However, precursors of cytotoxic cells remained and appeared to lose their OX-19 markers during activation. We have interpreted the results by using a speculative model that involves separate pathways of induction to cytotoxicity and IL-2 synthesis. We propose that the OX-19 marker is associated with the interleukin 1 receptor and that the latter is required for the IL-2 production pathway but not for activation to cytotoxicity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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