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. 1986 May;83(10):3447–3450. doi: 10.1073/pnas.83.10.3447

Restriction fragment length polymorphism caused by a deletion within the human c-abl gene (ABL).

D Q Xu, F Galibert
PMCID: PMC323532  PMID: 3010299

Abstract

A restriction fragment length polymorphism at the human c-abl locus (ABL) has been detected in 67 unrelated individuals by agarose gel electrophoresis and Southern blot hybridization using 32P-labeled v-abl probes. This polymorphism is generated by the existence of two alleles, a and b, which are in Hardy-Weinberg equilibrium, with frequencies of 94.8% and 5.2%, respectively. The minor allele, b, is due to a deletion of about 500 base pairs in an intron located downstream of the codon for the phosphate-acceptor tyrosine residue of the c-abl gene product.

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