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. 1986 Jul;83(13):4641–4645. doi: 10.1073/pnas.83.13.4641

Exogenous glutathione protects intestinal epithelial cells from oxidative injury.

L H Lash, T M Hagen, D P Jones
PMCID: PMC323797  PMID: 3460063

Abstract

Exogenous GSH provided rat small-intestinal epithelial cells with significant protection against injury induced by t-butyl hydroperoxide or menadione. This protection was found to be dependent upon uptake of intact GSH. Uptake of GSH occurred by a Na+-dependent electrogenic system found in the basolateral membrane. Thus, rat small-intestinal epithelial cells can utilize plasma GSH to support intracellular detoxication systems that function in protection against chemically induced injury.

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Selected References

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