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. 1986 Jul;83(14):5150–5154. doi: 10.1073/pnas.83.14.5150

Early replication and expression of oocyte-type 5S RNA genes in a Xenopus somatic cell line carrying a translocation.

D R Guinta, J Y Tso, S Narayanswami, B A Hamkalo, L J Korn
PMCID: PMC323908  PMID: 3460086

Abstract

In Xenopus somatic cells, the somatic-type 5S RNA genes replicate early in S phase, bind the transcription factor TFIIIA, and are expressed; in contrast, the late replicating oocyte-type genes do not bind TFIIIA and are transcriptionally inactive. These facts support a model in which the order of replication of the somatic-type versus the oocyte-type 5S genes causes their differential expression in somatic cells due to sequestration of TFIIIA by the early-replicating somatic genes. Here we provide further evidence for the model by showing that in one Xenopus cell line in which some oocyte-type 5S genes are translocated, some oocyte-type 5S genes replicate early and are expressed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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