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. 1986 Jul;83(14):5165–5169. doi: 10.1073/pnas.83.14.5165

Analysis of the human alpha-globin gene cluster reveals a highly informative genetic locus.

D R Higgs, J S Wainscoat, J Flint, A V Hill, S L Thein, R D Nicholls, H Teal, H Ayyub, T E Peto, A G Falusi, et al.
PMCID: PMC323911  PMID: 3014536

Abstract

Extensive molecular studies have characterized 15 dimorphic and 2 multiallelic genetic markers within the human alpha-globin gene cluster. Analysis of these markers in 9 populations has shown that the alpha-globin locus is remarkably polymorphic and is therefore an ideal marker on chromosome 16 for the construction of a human genetic linkage map. The combined analysis of 9 polymorphic markers has established alpha-globin haplotypes that provide the means to study the molecular genetics and common mutants of this cluster. The novel association of a conventional restriction fragment length polymorphism haplotype and linked, hypervariable regions of DNA should allow a comparison of the rate of change of such markers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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