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. 1980 Mar 11;8(5):1133–1143. doi: 10.1093/nar/8.5.1133

On the substrate specificity of a damage-specific DNA binding protein from human cells.

R S Feldberg
PMCID: PMC323978  PMID: 6893749

Abstract

The nature of the lesion recognized by a damage-specific DNA binding protein from human cells was investigated by examining the substrate specificity of this protein. Protein-recognizable damage was introduced into both T7 DNA and Poly d(A-T) at relatively low UV fluences. In addition, the protein demonstrated binding to both nitrous acid- and bisulfite-treated DNA, but not to DNA crosslinked with trioxsalen plus near-UV nor to non-irradiated uracil-containing DNA. These results suggest that this protein could be recognizing minor helix distortions in DNA rather than any one single lesion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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