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. 1980 Apr 11;8(7):1625–1641. doi: 10.1093/nar/8.7.1625

Effects of novobiocin on adenovirus DNA synthesis and encapsidation.

J C D'Halluin, M Milleville, P Boulanger
PMCID: PMC324021  PMID: 7433126

Abstract

Novobiocin, an inhibitor of DNA gyrase implicated in bacterial and likely mammalian, chromosome replication, inhibited the initiation, but not the elongation of human adenovirus DNA replicative synthesis. The inhibition was partially reversible, even in the presence of protein synthesis inhibitor. Novobiocin inhibited also the encapsidation of viral DNA, and this effect was independent of the block in DNA replication. It was suggested that novobiocin acted on two different functions, one involved in viral DNA replication initiation, the other in DNA encapsidation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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