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Diene (1) and dienophile (2) undergo a pericyclic [4+2] cycloaddition (3) to form a chiral cyclohexene ring (4). Also shown in (3) is a schematic of the design target active site, with hydrogen bond acceptor and donor groups activating the diene and dienophile and a complementary binding pocket holding the two substrates in an orientation optimal for catalysis.
