Abstract
A theoretical study of indices potentially useful for investigation of the reactivity of the recently discovered Z-DNA double helix is presented. The electrostatic potential minima and the steric accessibility of reactive sites are calculated. The effect of screening the phosphate groups by metal cations is investigated. The results are compared with those for the B-DNA double helix.
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Selected References
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- Arnott S., Chandrasekaran R., Birdsall D. L., Leslie A. G., Ratliff R. L. Left-handed DNA helices. Nature. 1980 Feb 21;283(5749):743–745. doi: 10.1038/283743a0. [DOI] [PubMed] [Google Scholar]
- Lavery R., Pullman A., Pullman B. The electrostatic molecular potential of yeast tRNAPhe. (I). The potential due to the phosphate backbone. Nucleic Acids Res. 1980 Mar 11;8(5):1061–1079. doi: 10.1093/nar/8.5.1061. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pohl F. M., Jovin T. M. Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC). J Mol Biol. 1972 Jun 28;67(3):375–396. doi: 10.1016/0022-2836(72)90457-3. [DOI] [PubMed] [Google Scholar]
- Pullman B., Perahia D., Cauchy D. The molecular electrostatic potential of the B-DNA helix. VI. The regions of the base pairs in poly (dG.dC) and poly (dA.dT). Nucleic Acids Res. 1979 Aug 24;6(12):3821–3829. doi: 10.1093/nar/6.12.3821. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thiyagarajan P., Ponnuswamy P. K. Solvent accessibility study on tRNAPhe. Biopolymers. 1979 Sep;18(9):2233–2247. doi: 10.1002/bip.1979.360180911. [DOI] [PubMed] [Google Scholar]
- Wang A. H., Quigley G. J., Kolpak F. J., Crawford J. L., van Boom J. H., van der Marel G., Rich A. Molecular structure of a left-handed double helical DNA fragment at atomic resolution. Nature. 1979 Dec 13;282(5740):680–686. doi: 10.1038/282680a0. [DOI] [PubMed] [Google Scholar]