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. 1980 Nov 25;8(22):5507–5517. doi: 10.1093/nar/8.22.5507

Solid-phase synthesis of polynucleotides. IV. Usage of polystyrene resins for the synthesis of polydeoxyribonucleotides by the phosphostriester method.

K Miyoshi, R Arentzen, T Huang, K Itakura
PMCID: PMC324317  PMID: 7465420

Abstract

Contrary to the expectation, the Merrifield polystyrene resin, 2% cross-linked by divinylbenzene, is as efficient as the polyacrylmorpholide resin for the synthesis of polydeoxyribonucleotides using a phosphotriester method. On the Merrifield resin, the tetradecamer, dTpCpGpTpCpApApCpTpGpGpCpTpT, and the hexadecamer, dCpCpApGpTpCpApCpGpApCpGpTpTpGpT, were synthesized by the phosphotriester method using di and trinucleotide blocks as coupling units.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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