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. 1980 Dec 11;8(23):5859–5873. doi: 10.1093/nar/8.23.5859

Two classes of Mu lig mutants: the thermosensitives for integration and replication and the hyperproducers for ligase.

L Paolozzi, P Ghelardini, J C Liebart, A Capozzoni, C Marchelli
PMCID: PMC324347  PMID: 7008031

Abstract

We have previously shown that Mu restores an active DNA replication at non-permissive temperature in E. coli K12 ligts7 strains. In this paper we describe two new types of phage mutants for the Mu lig function. The Mu ligts mutants are conditional lethals defective for both integration and replication of DNA, unable to 'complement' the bacterial lig mutation; the map between B and lys. The mutants of the other type, on the other hand, are able to restore to a maximum level the activity impaired by the ligts7 mutation in the host. We suggest the hypothesis that the product of Mu lig gene could be part of a complex as a topoisomerase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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