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. 1980 Oct 24;8(20):4791–4802. doi: 10.1093/nar/8.20.4791

Identification by nucleotide sequence analysis of a goat pseudoglobin gene.

M L Cleary, J R Haynes, E A Schon, J B Lingrel
PMCID: PMC324388  PMID: 6255432

Abstract

We have recently prepared a recombinant library of goat genomic DNA and have isolated clones containing th known goat globin genes. These include the alpha, gamma, beta C and beta A genes. In addition to these, another beta-like sequence has been observed. In this communication we report the complete nucleotide sequence of this gene, excluding a portion of the large intervening sequence. Several features suggest that this is a non-functional or pseudoglobin gene. The alterations include a frameshift mutation, substitution of the heme-binding histidines, a mutated termination codon, a change in the GT/AG excision sequence of the 5' end of the first intervening sequence, an AT rich sequence in the 3' untranslated region, and a mutated Hogness-Goldberg box. We conclude that this gene cannot function in the synthesis of globin.

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Selected References

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