Table 5.
CRP | IL-1β | IL-2 | IL-4 | IL-5 | IL-6 | IL-10 | IL-12 p70 | IL-13 | TNFα | IL-1RA | sIL-1R ll | sIL-2Ra | sIL-4R | sIL-6R | IL-12 p40 | sTNF-R1 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IL-1β | 0.02 | ||||||||||||||||
IL-2 | 0.03 | 0.77*** | |||||||||||||||
IL-4 | 0.06 | 0.20*** | 0.22*** | ||||||||||||||
IL-5 | 0.01 | 0.22*** | 0.21*** | 0.58*** | |||||||||||||
IL-6 | 0.12* | 0.29*** | 0.28*** | 0.84*** | 0.62*** | ||||||||||||
IL-10 | 0.07 | 0.36*** | 0.32*** | 0.11* | 0.37*** | 0.21*** | |||||||||||
IL-12 p70 | −0.02 | 0.49*** | 0.45*** | 0.14** | 0.35*** | 0.35*** | 0.66*** | ||||||||||
IL-13 | 0.00 | 0.31*** | 0.27*** | 0.65*** | 0.43*** | 0.68*** | 0.36*** | 0.41*** | |||||||||
TNFα | 0.07 | 0.30*** | 0.23*** | 0.12* | 0.19*** | 0.21*** | 0.34*** | 0.34*** | 0.19*** | ||||||||
IL-1RA | 0.03 | 0.35*** | 0.36*** | 0.05 | 0.04 | 0.04 | 0.06 | 0.11* | 0.06 | −0.03 | |||||||
sIL-1Rll | 0.12 | −0.02 | −0.01 | 0.07 | 0.10 | 0.05 | 0.07 | 0.01 | 0.04 | 0.12 | −0.06 | ||||||
sIL-2Ra | 0.19** | 0.03 | 0.02 | 0.06 | 0.05 | 0.04 | 0.11 | −0.03 | −0.01 | 0.15* | 0.00 | 0.41*** | |||||
sIL-4R | −0.05 | 0.18** | 0.21*** | 0.13* | 0.13* | 0.18** | 0.09 | 0.25*** | 0.11 | 0.09 | 0.09 | 0.20*** | 0.33*** | ||||
sIL-6R | 0.05 | −0.02 | −0.04 | −0.01 | −0.03 | −0.01 | −0.08 | −0.10 | −0.01 | 0.07 | −0.15* | 0.01 | −0.01 | −0.08 | |||
IL-12p40 | 0.04 | 0.29*** | 0.26*** | 0.08 | 0.07 | 0.04 | 0.18*** | 0.12* | 0.11* | 0.14** | 0.56*** | −0.04 | 0.18** | 0.05 | −0.10 | ||
sTNF-R1 | 0.10 | 0.19*** | 0.16*** | 0.01 | 0.01 | 0.03 | 0.09 | 0.03 | 0.02 | 0.11* | 0.46*** | 0.00 | 0.25*** | 0.10 | −0.08 | 0.57*** | |
sTNF-R2 | 0.10 | −0.06 | −0.08 | −0.07 | 0.02 | −0.05 | 0.02 | −0.07 | −0.06 | 0.11* | −0.05 | 0.04 | 0.16** | −0.10 | 0.14* | 0.08 | 0.18*** |
Note: CRP: C-reactive protein, IL: interleukin, RA: receptor antagonist, Ra: receptor alpha, R: receptor, TNF: tumor necrosis factor. Cytokines and cytokine modulators were log transformed.
Coefficients with * are significant at P< 0.01, with ** at P<0.001, and with *** at P<0.0001.
Correlations are based on a different number of subjects for each pair of markers, ranging from 390 to 616 subjects.
All models adjusted for study (NYUWHS-OVCA, NYUWHS-NHL, ORDET, NSHDS), age at blood sampling, and body mass index.