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. Author manuscript; available in PMC: 2012 Jan 3.
Published in final edited form as: Immunotherapy. 2012 Jan;4(1):1–4. doi: 10.2217/imt.11.144

Fig 1. Rapamycin induces autophagy in human Th1 cell.

Fig 1

CD4+ T cells were co-stimulated with anti-CD3, anti-CD28 and cultured for 6 days in media containing rhlL2 (20 IU/ml), INF-α2b (1 M IU/ml), and rapamycin. (A) Resultant CD4+ Th1 cells expressed autophagosomes by electron microscopy. (B) Culture initiation with CD4+ T cells knocked-down for Beclin-1 expression by siRNA methodology had greatly reduced autophagy.