Table 1.
Demographic and clinical characteristics of the substance dependent (SD) and healthy control (HC) subjects
| Subject Variable | SD/HH (N=12) | SD/HLLL (N=25) | HC/HH (N=8) | HC/HLLL (N=20) |
|---|---|---|---|---|
| Race | ||||
| Caucasian | 4 (33.3%) | 17 (68%) | 6 (75%) | 11 (55%) |
| African American | 6 (50%) | 6(24%) | 1(12.5%) | 6(30%) |
| Hispanic | 0 | 2(8%) | 1 (12.5%) | 2 (10%) |
| Other | 2 (16.7%) | 0 | 0 | 1 (5%) |
| Gender (Male) | 7 (58.3%) | 17 (68%) | 6 (75%) | 9 (45%) |
| Age * | 37.6 (7.06) | 37.6 (5.85) | 34.8 (9.85) | 29.1 (9.85) |
| Average Years of Education * | 13.1 (1.78) | 12.6 (1.23) | 14.5 (1.97) | 14.9 (1.77) |
| Average Years of Alcohol Use | 12.4 (8.32) | 13.7 (8.13) | 8.9 (8.41) | 7.5 (8.46) |
| Average Days of Alcohol Use/Month* | 14.8 (9.04) | 15.9 (11.97) | 3.2 (3.35) | 5.8 (8.33) |
| Total Amount (drinks) of Alcohol Use /Month* | 187.7 (210.18) | 242.3 (237.5) | 8.0 (6.93) | 11.5 (10.35) |
| Average Years of Cocaine Use | 9.54 (4.72) | 8.00 (7.26) | - | - |
| Average Days of Cocaine Use/Month | 21.00 (10.43) | 14.24 (13.23) | - | - |
| Total Amount (g) of Cocaine Use/Month | 44.80 (38.22) | 33.88 (23.14) | - | - |
| Average Days of Marijuana Use/Month | 9.5 (12.94) | 0.22 (0.52) | - | - |
| Total Amount (g) of Marijuana Use/Month | 23.52 (26.60) | 0.6 (0.94) | - | - |
| Regular Cigarette Smokers: N(%)* | 8 (66.67%) | 23 (92%) | 4 (50%) | 5 (25%) |
| Lifetime Prevalence of PTSD | 2 (16.7%) | 2 (8%) | 0 | 2 (10%) |
| Lifetime Other Anxiety Disorders | 3 (25%) | 3 (12%) | 0 | 0 |
| Lifetime Major Depression | 1 (8.3%) | 7 (28%) | 2 (25%) | 1 (5%) |
Note:
*
SD significantly different from HC group, p<0.05, but no differences between HH and HLLL groups; HH: NPY Diplotype predicting high NPY mRNA expression; HLLL: NPY diplotype predicting moderate and low NPY mRNA expression; PTSD: post-traumatic stress disorder