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. Author manuscript; available in PMC: 2012 Jul 5.
Published in final edited form as: Oncogene. 2011 Jun 6;31(1):27–38. doi: 10.1038/onc.2011.209

Figure 2.

Figure 2

miR-296-regulation of cell migration and invasion. (a) The indicated cell types were transfected with antagomir-miR-296 (a-miR-296) or pre-miR-296 (p-miR-296) and analyzed in a wound healing assay after 24 h. Bottom, quantification of cell migration. Control, non-transfected. Scale bar, 100 μm (*, P=0.027; **, P =0.0011; ***, P <0.001). (b) HMEC were transfected as indicated in A, and analyzed for Matrigel invasion in a Transwell assay in the presence of serum (**, P=0.0098; *** P<0.001). (c) Breast adenocarcinoma MCF-7 cells were transfected as indicated and analyzed for colony formation in soft agar after 2 weeks (*, P=0.013). Values are mean ± s.e.m.