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. 1997;24(4):349–352.

Coronary artery ectasia in Egyptian patients with coronary artery disease.

H M Waly 1, M A Elayda 1, V V Lee 1, G el-Said 1, G J Reul 1, R J Hall 1
PMCID: PMC325479  PMID: 9456489

Abstract

We conducted a retrospective study of 45 Egyptian patients with coronary artery ectasia who underwent coronary bypass grafting at our institution between 1980 and 1995. We examined the anatomic distribution and type of coronary ectasia and its association with coronary risk factors in these patients, and evaluated the severity of their coronary artery disease. We compared these findings with those from a group of 230 Egyptian patients who did not have coronary ectasia. These patients also underwent coronary artery bypass grafting between 1980 and 1995 at our institution. Obesity was present in 60% of the patients who had coronary artery ectasia, compared with 42% of patients who did not have ectasia (P < 0.01). Coronary artery ectasia was not related to any coronary risk factors other than obesity. However, patients who had ectasia did have a higher rate of triple-vessel coronary artery disease than did patients without ectasia (82% vs 67%, P < 0.05). Of the coronary vessels affected by ectasia, 43% were left anterior descending arteries. Diffuse disease was noted in 84% of all ectatic segments. We conclude that in this patient population, 2 conditions had a positive correlation with coronary ectasia: obesity and the severity of coronary artery disease.

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Selected References

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  1. Aintablian A., Hamby R. I., Hoffman I., Kramer R. J. Coronary ectasia: incidence and results of coronary bypass surgery. Am Heart J. 1978 Sep;96(3):309–315. doi: 10.1016/0002-8703(78)90041-8. [DOI] [PubMed] [Google Scholar]
  2. Befeler B., Aranda M. J., Embi A., Mullin F. L., El-Sherif N., Lazzara R. Coronary artery aneurysms: study of the etiology, clinical course and effect on left ventricular function and prognosis. Am J Med. 1977 Apr;62(4):597–607. doi: 10.1016/0002-9343(77)90423-5. [DOI] [PubMed] [Google Scholar]
  3. Bizbiz L., Bonithon-Kopp C., Ducimetierè P., Berr C., Alperovitch A., Robert L. Relation of serum elastase activity to ultrasonographically assessed carotid artery wall lesions and cardiovascular risk factors. The EVA study. Atherosclerosis. 1996 Feb;120(1-2):47–55. doi: 10.1016/0021-9150(95)05676-9. [DOI] [PubMed] [Google Scholar]
  4. Calvo Rey C., Borque Andrés C., del Castillo Martín F., García Piñeiro A., García Hortelano J., García García M., Rubio Vidal D., Moreno Granados F. Enfermedad de Kawasaki; complicaciones y evolución. A propósito de 38 casos. An Esp Pediatr. 1993 Nov;39(5):423–427. [PubMed] [Google Scholar]
  5. Camejo G. The interaction of lipids and lipoproteins with the intercellular matrix of arterial tissue: its possible role in atherogenesis. Adv Lipid Res. 1982;19:1–53. doi: 10.1016/b978-0-12-024919-0.50007-2. [DOI] [PubMed] [Google Scholar]
  6. Chaithiraphan S., Goldberg E., O'Reilly M., Jootar P. Multiple aneurysms of coronary artery in sclerodermal heart disease. Angiology. 1973 Feb;24(2):86–93. doi: 10.1177/000331977302400204. [DOI] [PubMed] [Google Scholar]
  7. Chamberlain J. L., 3rd, Perry L. W. Infantile periarteritis nodosa with coronary and brachial aneurysms: a case diagnosed during life. J Pediatr. 1971 Jun;78(6):1039–1042. doi: 10.1016/s0022-3476(71)80439-0. [DOI] [PubMed] [Google Scholar]
  8. Crook B. R., Raftery E. B., Oram S. Mycotic aneurysms of coronary arteries. Br Heart J. 1973 Jan;35(1):107–109. doi: 10.1136/hrt.35.1.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cullen S., Duff D. F., Denham B., Ward O. C. Cardiovascular manifestations in Kawasaki disease. Ir J Med Sci. 1989 Oct;158(10):253–256. doi: 10.1007/BF02943701. [DOI] [PubMed] [Google Scholar]
  10. DAOUD A. S., PANKIN D., TULGAN H., FLORENTIN R. A. Aneurysms of the coronary artery. Report of ten cases and review of literature. Am J Cardiol. 1963 Feb;11:228–237. doi: 10.1016/0002-9149(63)90064-x. [DOI] [PubMed] [Google Scholar]
  11. DENHAM S. W. Syphilitic aneurysm of the left coronary artery. AMA Arch Pathol. 1951 Jun;51(6):661–665. [PubMed] [Google Scholar]
  12. Davis R. L., Waller P. L., Mueller B. A., Dykewicz C. A., Schonberger L. B. Kawasaki syndrome in Washington State. Race-specific incidence rates and residential proximity to water. Arch Pediatr Adolesc Med. 1995 Jan;149(1):66–69. doi: 10.1001/archpedi.1995.02170130068016. [DOI] [PubMed] [Google Scholar]
  13. Frithz G., Cullhed I., Björk L. Congenital localized coronary artery aneurysm without fistula. Report of a preoperatively diagnosed case. Am Heart J. 1968 Nov;76(5):674–679. doi: 10.1016/0002-8703(68)90166-x. [DOI] [PubMed] [Google Scholar]
  14. Fuster V., Badimon L., Badimon J. J., Chesebro J. H. The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med. 1992 Jan 30;326(5):310–318. doi: 10.1056/NEJM199201303260506. [DOI] [PubMed] [Google Scholar]
  15. Glagov S., Weisenberg E., Zarins C. K., Stankunavicius R., Kolettis G. J. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987 May 28;316(22):1371–1375. doi: 10.1056/NEJM198705283162204. [DOI] [PubMed] [Google Scholar]
  16. Hartnell G. G., Parnell B. M., Pridie R. B. Coronary artery ectasia. Its prevalence and clinical significance in 4993 patients. Br Heart J. 1985 Oct;54(4):392–395. doi: 10.1136/hrt.54.4.392. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Imahori S., Bannerman R. M., Graf C. J., Brennan J. C. Ehlers-Danlos syndrome with multiple arterial lesions. Am J Med. 1969 Dec;47(6):967–977. doi: 10.1016/0002-9343(69)90210-1. [DOI] [PubMed] [Google Scholar]
  18. Kato H., Ichinose E., Yoshioka F., Takechi T., Matsunaga S., Suzuki K., Rikitake N. Fate of coronary aneurysms in Kawasaki disease: serial coronary angiography and long-term follow-up study. Am J Cardiol. 1982 May;49(7):1758–1766. doi: 10.1016/0002-9149(82)90256-9. [DOI] [PubMed] [Google Scholar]
  19. Katzel L. I., Busby-Whitehead M. J., Goldberg A. P. Adverse effects of abdominal obesity on lipoprotein lipids in healthy older men. Exp Gerontol. 1993 Jul-Oct;28(4-5):411–420. doi: 10.1016/0531-5565(93)90067-n. [DOI] [PubMed] [Google Scholar]
  20. Kirschner L. P., Perloff J. K., Twigg H. L. Coronary artery ectasia in chronic cyanotic congenital heart disease. Med Ann Dist Columbia. 1969 Mar;38(3):123–passim. [PubMed] [Google Scholar]
  21. Kryzer T. C., Derkay C. S. Kawasaki disease: five-year experience at Children's National Medical Center. Int J Pediatr Otorhinolaryngol. 1992 May;23(3):211–220. doi: 10.1016/0165-5876(92)90102-u. [DOI] [PubMed] [Google Scholar]
  22. Mabuchi H., Michishita I., Sakai Y., Sakai T., Ikawa T., Genda A., Takeda R. Coronary ectasia in a homozygous patient with familial hypercholesterolemia. Atherosclerosis. 1986 Jan;59(1):43–46. doi: 10.1016/0021-9150(86)90031-6. [DOI] [PubMed] [Google Scholar]
  23. Markis J. E., Joffe C. D., Cohn P. F., Feen D. J., Herman M. V., Gorlin R. Clinical significance of coronary arterial ectasia. Am J Cardiol. 1976 Feb;37(2):217–222. doi: 10.1016/0002-9149(76)90315-5. [DOI] [PubMed] [Google Scholar]
  24. Oliveros R. A., Falsetti H. L., Carroll R. J., Heinle R. A., Ryan G. F. Atherosclerotic coronary artery aneurysm. Report of five cases and review of literature. Arch Intern Med. 1974 Dec;134(6):1072–1076. doi: 10.1001/archinte.134.6.1072. [DOI] [PubMed] [Google Scholar]
  25. Podet E. J., Shaffer D. R., Gianturco S. H., Bradley W. A., Yang C. Y., Guyton J. R. Interaction of low density lipoproteins with human aortic elastin. Arterioscler Thromb. 1991 Jan-Feb;11(1):116–122. doi: 10.1161/01.atv.11.1.116. [DOI] [PubMed] [Google Scholar]
  26. Schwartz C. J., Ardlie N. G. Observations on the natural history of coronary artery disease. Australas Ann Med. 1966 May;15(2):101–109. doi: 10.1111/imj.1966.15.2.101. [DOI] [PubMed] [Google Scholar]
  27. Schwartz C. J., Valente A. J., Sprague E. A., Kelley J. L., Nerem R. M. The pathogenesis of atherosclerosis: an overview. Clin Cardiol. 1991 Feb;14(2 Suppl 1):I1–16. doi: 10.1002/clc.4960141302. [DOI] [PubMed] [Google Scholar]
  28. Swaye P. S., Fisher L. D., Litwin P., Vignola P. A., Judkins M. P., Kemp H. G., Mudd J. G., Gosselin A. J. Aneurysmal coronary artery disease. Circulation. 1983 Jan;67(1):134–138. doi: 10.1161/01.cir.67.1.134. [DOI] [PubMed] [Google Scholar]
  29. Tunick P. A., Slater J., Kronzon I., Glassman E. Discrete atherosclerotic coronary artery aneurysms: a study of 20 patients. J Am Coll Cardiol. 1990 Feb;15(2):279–282. doi: 10.1016/s0735-1097(10)80049-x. [DOI] [PubMed] [Google Scholar]
  30. Vizcaíno-Alarcón A., Arévalo-Salas A., Rodríguez-López A. M., Sadowinski-Pine S. Enfermedad de Kawasaki en niños mexicanos. Bol Med Hosp Infant Mex. 1991 Jun;48(6):398–408. [PubMed] [Google Scholar]
  31. Waly H. M., Elayda M. A., Lee V. V., el-Said G., Reul G. J., Hall R. J. Risk factor analysis among Egyptian patients who underwent coronary artery bypass surgery. Tex Heart Inst J. 1997;24(3):204–208. [PMC free article] [PubMed] [Google Scholar]

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