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. 1998;25(4):265–271.

The HeartMate left ventricular assist system. Overview and 12-year experience.

O H Frazier 1, T J Myers 1, B Radovancević 1
PMCID: PMC325571  PMID: 9885103

Abstract

Cardiac transplantation has become a widely accepted option for treating end-stage heart failure. As the waiting time for donor hearts grows, new generations of left ventricular assist systems are being developed for patients awaiting transplantation. Great strides have been made in the study and use of such devices, both as temporary support and (perhaps ultimately) as permanent implants. The Texas Heart Institute has been involved with the development of the HeartMate left ventricular assist systems, which have been used almost exclusively as a temporary bridge. Herein we review our 12-year clinical experience with the HeartMate left ventricular assist systems as a bridge to transplantation and as a long-term circulatory assist device that aids in cardiac repair. Trials of the HeartMate as a permanent support system for patients with end-stage heart failure who are not suitable candidates for transplantation are currently under way.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashton R. C., Jr, Goldstein D. J., Rose E. A., Weinberg A. D., Levin H. R., Oz M. C. Duration of left ventricular assist device support affects transplant survival. J Heart Lung Transplant. 1996 Nov;15(11):1151–1157. [PubMed] [Google Scholar]
  2. Cloy M. J., Myers T. J., Stutts L. A., Macris M. P., Frazier O. H. Hospital charges for conventional therapy versus left ventricular assist system therapy in heart transplant patients. ASAIO J. 1995 Jul-Sep;41(3):M535–M539. doi: 10.1097/00002480-199507000-00068. [DOI] [PubMed] [Google Scholar]
  3. DeRose J. J., Jr, Umana J. P., Argenziano M., Catanese K. A., Gardocki M. T., Flannery M., Levin H. R., Sun B. C., Rose E. A., Oz M. C. Implantable left ventricular assist devices provide an excellent outpatient bridge to transplantation and recovery. J Am Coll Cardiol. 1997 Dec;30(7):1773–1777. doi: 10.1016/s0735-1097(97)00396-3. [DOI] [PubMed] [Google Scholar]
  4. Frazier O. H., Benedict C. R., Radovancevic B., Bick R. J., Capek P., Springer W. E., Macris M. P., Delgado R., Buja L. M. Improved left ventricular function after chronic left ventricular unloading. Ann Thorac Surg. 1996 Sep;62(3):675–682. doi: 10.1016/s0003-4975(96)00437-7. [DOI] [PubMed] [Google Scholar]
  5. Frazier O. H. First use of an untethered, vented electric left ventricular assist device for long-term support. Circulation. 1994 Jun;89(6):2908–2914. doi: 10.1161/01.cir.89.6.2908. [DOI] [PubMed] [Google Scholar]
  6. Frazier O. H., Rose E. A., McCarthy P., Burton N. A., Tector A., Levin H., Kayne H. L., Poirier V. L., Dasse K. A. Improved mortality and rehabilitation of transplant candidates treated with a long-term implantable left ventricular assist system. Ann Surg. 1995 Sep;222(3):327–338. doi: 10.1097/00000658-199509000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Frazier O. H. The development of an implantable, portable, electrically powered left ventricular assist device. Semin Thorac Cardiovasc Surg. 1994 Jul;6(3):181–187. [PubMed] [Google Scholar]
  8. Hosenpud J. D., Bennett L. E., Keck B. M., Fiol B., Novick R. J. The Registry of the International Society for Heart and Lung Transplantation: fourteenth official report--1997. J Heart Lung Transplant. 1997 Jul;16(7):691–712. [PubMed] [Google Scholar]
  9. Massad M. G., McCarthy P. M., Smedira N. G., Cook D. J., Ratliff N. B., Goormastic M., Vargo R. L., Navia J., Young J. B., Stewart R. W. Does successful bridging with the implantable left ventricular assist device affect cardiac transplantation outcome? J Thorac Cardiovasc Surg. 1996 Nov;112(5):1275–1283. doi: 10.1016/S0022-5223(96)70141-1. [DOI] [PubMed] [Google Scholar]
  10. Myers T. J., Catanese K. A., Vargo R. L., Dressler D. K. Extended cardiac support with a portable left ventricular assist system in the home. ASAIO J. 1996 Sep-Oct;42(5):M576–M579. doi: 10.1097/00002480-199609000-00053. [DOI] [PubMed] [Google Scholar]
  11. Müller J., Wallukat G., Weng Y. G., Dandel M., Spiegelsberger S., Semrau S., Brandes K., Theodoridis V., Loebe M., Meyer R. Weaning from mechanical cardiac support in patients with idiopathic dilated cardiomyopathy. Circulation. 1997 Jul 15;96(2):542–549. doi: 10.1161/01.cir.96.2.542. [DOI] [PubMed] [Google Scholar]
  12. Nishimura M., Radovancevic B., Odegaard P., Myers T., Springer W., Frazier O. H. Exercise capacity recovers slowly but fully in patients with a left ventricular assist device. ASAIO J. 1996 Sep-Oct;42(5):M568–M570. doi: 10.1097/00002480-199609000-00050. [DOI] [PubMed] [Google Scholar]
  13. Norman J. C., Brook M. I., Cooley D. A., Klima T., Kahan B. D., Frazier O. H., Keats A. S., Hacker J., Massin E. K., Duncan J. M. Total support of the circulation of a patient with post-cardiotomy stone-heart syndrome by a partial artificial heart (ALVAD) for 5 days followed by heart and kidney transplantation. Lancet. 1978 May 27;1(8074):1125–1127. doi: 10.1016/s0140-6736(78)90301-x. [DOI] [PubMed] [Google Scholar]
  14. O'Connell J. B., Bristow M. R. Economic impact of heart failure in the United States: time for a different approach. J Heart Lung Transplant. 1994 Jul-Aug;13(4):S107–S112. [PubMed] [Google Scholar]
  15. Pennington D. G., McBride L. R., Peigh P. S., Miller L. W., Swartz M. T. Eight years' experience with bridging to cardiac transplantation. J Thorac Cardiovasc Surg. 1994 Feb;107(2):472–481. [PubMed] [Google Scholar]
  16. Portner P. M., Oyer P. E., Pennington D. G., Baumgartner W. A., Griffith B. P., Frist W. R., Magilligan D. J., Jr, Noon G. P., Ramasamy N., Miller P. J. Implantable electrical left ventricular assist system: bridge to transplantation and the future. Ann Thorac Surg. 1989 Jan;47(1):142–150. doi: 10.1016/0003-4975(89)90256-7. [DOI] [PubMed] [Google Scholar]
  17. Radovancevic B., Frazier O. H., Duncan J. M. Implantation technique for the HeartMate left ventricular assist device. J Card Surg. 1992 Sep;7(3):203–207. doi: 10.1111/j.1540-8191.1992.tb00803.x. [DOI] [PubMed] [Google Scholar]
  18. Westaby S., Jin X. Y., Katsumata T., Taggart D. P., Coats A. J., Frazier O. H. Mechanical support in dilated cardiomyopathy: signs of early left ventricular recovery. Ann Thorac Surg. 1997 Nov;64(5):1303–1308. doi: 10.1016/S0003-4975(97)00910-7. [DOI] [PubMed] [Google Scholar]

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