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. 1983 Jan 25;11(2):477–488. doi: 10.1093/nar/11.2.477

Solid phase synthesis of polynucleotides. VIII. Synthesis of mixed oligodeoxyribonucleotides by the phosphotriester solid phase method.

Y Ike, S Ikuta, M Sato, T Huang, K Itakura
PMCID: PMC325727  PMID: 6828376

Abstract

A solid phase method for the simultaneous synthesis of mixed oligonucleotides using a phosphotriester approach has been developed. For this synthesis, a mixture of mono or dimeric coupling units is used, and a slight difference in the reactivity of those units is found. However, this difference does not hamper the simultaneous, mixed oligonucleotide synthesis, and the sequence analysis of a product demonstrates the existence of all desired sequences in the final mixture.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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