Table 5.
Intervention with vitamin D analogues (with / without calcium) on BMD.
| Study | Study design | n | Sex | Mean age (years) | Treatment | Length | Results |
|---|---|---|---|---|---|---|---|
| CT, controlled trial; F, female; M, male; Cl, Calcitriol; Ac, Alfacalcidol; Ca, Calcium;/d, daily; wkly, weekly;mths, months; yr, year; yrs, years | |||||||
| Vitamin D analogues | |||||||
| Sato et al. 1999 (70) | CT | 86 | M/F | 70 | 40 IU Ac/d | 2 yrs | Decreased loss of BMD compared to placebo |
| Ebeling et al. 2001 (72) | CT | 41 | M | 57.5 | 20 IU Cl/d | 2 yrs | No effect |
| Gallagher et al. 2001 (73) | CT | 489 | F | 72 | 20 IU Cl/d | 2 yrs | Increase in spine BMD |
| Vitamin D analogues with calcium | |||||||
| Sambrook et al. 1993 (111) | CT | 103 | M/F | 46 | 24 IU Cl & 1000 mg Ca/d | 1 yr | Reduced corticosteroid bone loss in the lumbar spine. |
| Orimo et al. 1994 (98) | CT | 80 | F | 70 | 40 IU Ac & 300 mg Ca/d | 1 yr | Increase in lumbar spine (L2-L4) BMD in 0.65% |
| Shikari et al. 1996 (99) | CT | 113 | F | 70 | 30 IU Ac & 300 mg Ca/d | 2 yrs | Increase in lumbar spine (L2-L4) BMD (1.81-2.32%) |
| Sato et al. 1997 (116) | CT | 64 | M/F | 68 | 40 IU Cl & 300 mg Ca/d | 6 mths | Improvement in BMD on intact side of stroke subjects |
| Lambrinoudaki et al. 1999 (118) | CT | 81 | F | 31 | 20 IU Cl & 1200 mg Ca/d | 2 yrs | Increase in BMD at lumbar spine |
| Stempfle et al. 1999 (86) | CT | 132 | M/F | 50 | 10 IU Cl & 1000 mg Ca/d | 3 yrs | No effect |
| Sambrook et al. 2000 (119) | CT | 65 | M/F | 46 | 20-30 IU Cc & 600 mg Ca/d | 2 yrs | Reduced bone loss in proximal femur |