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. 1983 Mar 25;11(6):1635–1643. doi: 10.1093/nar/11.6.1635

Tumor-associated mutations of rat mitochondrial transfer RNA genes.

M Taira, E Yoshida, M Kobayashi, K Yaginuma, K Koike
PMCID: PMC325825  PMID: 6300770

Abstract

Mitochondrial DNA is a sensitive target of chemical carcinogens (Backer and Weinstein (1980) Science 209, 297-299), suggesting that mutations of the mitochondrial genome occur in tumor cells. We examined this point by comparing mitochondrial DNA sequences in four rat tumors with those of normal rat liver. Some novel mutations found in the tRNA genes of tumor mitochondria were as follows: nucleotides deletions in the aminoacyl-acceptor stem of the tRNATyr gene or in the anticodon stem of the tRNATrp gene and insertions in the "YpsiC" loop of the tRNACys gene. These structures are extraordinary compared with those of the tRNA genes of other mammals, indicating that these mutations are each associated with a corresponding tumor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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