Table 4. Univariate and Multivariate Analysis for DFS and OS in DNMT3A exon 23 mutated patients.
Analysis of covariates associated with DFS and OS. P of the univariate analysis is the p value of the Log rank test. HR is the value of the hazard ratio. 95% CI is the 95% confident interval of the hazard ratio. Data of AML patients with DNMT3A exon 23 mutations were complete and were included in the Cox proportional-hazards regression. NPM1: Nucleophosmin; FLT3-ITD: internal tandem duplication of the FLT3 gene; Allo-SCT: Allogeneic stem-cell transplantation; Ida: idarubicin; WBC: white blood cell count.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| DFS | p | HR | 95% CI | p | HR | 95% CI |
| Age > 50y | 0.94 | 1.04 | 0.35-3.09 | >0.1 | ||
| NPM1+/FLT3-ITD- | 0.49 | 0.70 | 0.25-1.95 | >0.1 | ||
| Normal karyotype | 0.95 | 1.04 | 0.33-3.24 | >0.1 | ||
| Allo-SCT | 0.13 | 0.45 | 0.16-1.26 | >0.1 | ||
| Ida treatment | 0.036 | 0.32 | 0.11-0.93 | 0.052 | 0.21 | 0.05-1.01 |
| WBC count > 30G/L | 0.55 | 1.43 | 0.45-4.56 | >0.1 | ||
| OS | ||||||
| Age > 50y | 0.76 | 1.17 | 0.43-3.14 | >0.1 | ||
| NPM1+/FLT3-ITD- | 0.52 | 0.74 | 0.29-1.89 | >0.1 | ||
| Normal karyotype | 0.88 | 1.08 | 0.39-2.99 | >0.1 | ||
| Allo-SCT | 0.06 | 0.41 | 0.16-1.04 | 0.053 | 0.36 | 0.12-1.01 |
| Ida treatment | 0.046 | 0.37 | 0.14-0.98 | 0.046 | 0.27 | 0.08-0.97 |
| WBC count > 30G/L | 0.2 | 2.06 | 0.69-6.13 | >0.1 | ||