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. 1983 Jun 25;11(12):4065–4075. doi: 10.1093/nar/11.12.4065

Histone hyperacetylation has little effect on the higher order folding of chromatin.

J D McGhee, J M Nickol, G Felsenfeld, D C Rau
PMCID: PMC326025  PMID: 6866766

Abstract

HeLa cells were grown in the presence of 10 mM sodium butyrate and soluble chromatin containing hyperacetylated histones was prepared by mild micrococcal nuclease digestion and sucrose gradient fractionation. Sedimentation and electric dichroism were used to study the cation-induced folding of this acetylated chromatin from the 10 nm filament to the 30 nm solenoid conformation. Although under some conditions acetylated chromatin appears slightly less condensed than control chromatin, the major conclusion is that hyperacetylation of histones does not in itself prevent the formation of the higher order chromatin solenoid.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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