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. 1983 Jul 11;11(13):4635–4643.

Gamma thalassemia resulting from the deletion of a gamma-globin gene.

P K Sukumaran, T Nakatsuji, M B Gardiner, A L Reese, J G Gilman, T H Huisman
PMCID: PMC326070  PMID: 6306596

Abstract

The first example of a deletion of one of the two gamma globin genes has been characterized through an analysis of the DNA of the heterozygous parent of a homozygous newborn, using restriction endonuclease mapping techniques. A deletion of approximately 5 kb was observed which was probably caused by an unequal crossing-over between the -G gamma- and -A gamma- genes resulting in the formation of a -G gamma A gamma- hybrid gene. Data on proportions of G gamma and A gamma chains in newborn babies assumed to be heterozygous for the hybrid and normal genes suggest that this hybrid gene may be producing its A gamma chain at levels normally seen only for the G gamma chain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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