Table 2. List and position of cysteine residues in mouse, rat, hamster, rabbit, pig, cow, dog, Northern tree shrew and human SR-BI.
Species | ND | NTD | ECD | ECD | ECD | ECD | ECD | ECD | CTD | CTD | CD |
---|---|---|---|---|---|---|---|---|---|---|---|
Mouse (9) | - | C21 | C251 | C280 | C321 | C323 | C334 | C384 | - | C462 | C470 |
Rat (8) | - | C21 | C251 | C280 | C321 | C323 | C334 | C384 | - | - | C470 |
Hamster (8) | - | C21 | C251 | C280 | C321 | C323 | C334 | C384 | C453 | - | C470 |
Rabbit (8) | - | C21 | C251 | C280 | C321 | C323 | C334 | C384 | - | - | C470 |
Pig (8) | - | - | C251 | C280 | C321 | C323 | C334 | C384 | C453 | - | C470 |
Cow (8) | - | - | C251 | C280 | C321 | C323 | C334 | C384 | C453 | - | C470 |
Dog (12)* | - | - | C251 | C280 | C321 | C323 | C334 | C384 | C453 | - | C470 |
Tree Shrew (9) | - | C21 | C251 | C280 | C321 | C323 | C334 | C384 | C453 | - | C470 |
Human (11) | C3 | C21 | C251 | C280 | C321 | C323 | C334 | C384 | C453 | C462 | C470 |
The predicted dog SR-BI sequence indicates the presence of 4 additional cysteine residues at positions 45, 53, 92, and 100 in the ECD. Positions of cysteine residues obtained from protein sequences using GenBank™ Accession numbers NM_016741, NP_113729.1, U11453, NM_001082788, NM_213967, DAA20570, XM_543366, EU379936, and NM_001082959 for mouse, rat, hamster, rabbit, pig, cow, dog, Northern tree shrew and human, respectively. ND, N-terminal domain; NTD, N-terminal transmembrane domain; ECD, extracellular domain; CTD, C-terminal transmembrane domain; CD, C-terminal domain