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. 1992;19(2):123–129.

Capillary Microscopy in Patients with Vasospastic and Arterial Occlusive Diseases

Michael JHM Jacobs 1,2, Igor D Gregoric 1,2, George J Reul 1,2
PMCID: PMC326268  PMID: 15227424

Abstract

Capillary microscopy and its application for diagnosis and therapeutic evaluation in patients with vasospastic and arterial occlusive disease are described in this report. Capillary microscopy is a noninvasive technique for measuring red blood cell velocity and for determining nutritional blood flow in the capillaries of the skin. This method can be applied in distinguishing patients with Raynaud's phenomenon from those with other disorders involving ischemia of the hand. In patients with atherosclerotic disease of the lower limb, microcirculatory observations can help determine how temperature increases and posturally induced microvascular constriction affect limbs with different degrees of ischemia. Capillary microscopy can also be used to help distinguish between patients who respond and those who do not respond to prolonged treatment for such disorders. Because capillary microscopy can be used to assess microcirculatory hemodynamics and autoregulatory mechanisms in cases of severe ischemia, it should be regarded as an essential tool in the evaluation of patients with upper- and lower-limb ischemia. (Texas Heart Institute Journal 1992;19:123-9)

Keywords: Capillaries, pathology

Keywords: microcirculation, physiopathology

Keywords: posture

Keywords: Raynaud's disease, diagnosis

Keywords: Raynaud's disease, therapy

Keywords: skin temperature, vasoconstriction, physiology

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bollinger A., Butti P., Barras J. P., Trachsler H., Siegenthaler W. Red blood cell velocity in nailfold capillaries of man measured by a television microscopy technique. Microvasc Res. 1974 Jan;7(1):61–72. doi: 10.1016/0026-2862(74)90037-5. [DOI] [PubMed] [Google Scholar]
  2. Bollinger A., Mahler F., Anliker M. M. Velocity of red blood cells in human nailfold capillaries. Acta Chir Scand Suppl. 1976;465:7–9. [PubMed] [Google Scholar]
  3. Coffman J. D., Cohen A. S. Total and capillary fingertip blood flow in Raynaud's phenomenon. N Engl J Med. 1971 Jul 29;285(5):259–263. doi: 10.1056/NEJM197107292850505. [DOI] [PubMed] [Google Scholar]
  4. Fagrell B., Fronek A., Intaglietta M. Capillary flow components and reactive hyperemia in human skin capillaries studied by clinical television microscopy. Bibl Anat. 1977;(16 Pt 2):112–115. [PubMed] [Google Scholar]
  5. Fagrell B., Lundberg G. A simplified evaluation of vital capillary microscopy for predicting skin viability in patients with severe arterial insufficiency. Clin Physiol. 1984 Oct;4(5):403–411. doi: 10.1111/j.1475-097x.1984.tb00125.x. [DOI] [PubMed] [Google Scholar]
  6. GILJE O., O'LEARY P. A., BALDES E. J. Capillary microscopic examination in skin diseases. AMA Arch Derm Syphilol. 1953 Aug;68(2):136–147. doi: 10.1001/archderm.1953.01540080020003. [DOI] [PubMed] [Google Scholar]
  7. Hoare M., Miles C., Girvan R., Ramsden J., Needham T., Pardy B., Nicolaides A. The effect of local cooling on digital systolic pressure in patients with Raynaud's syndrome. Br J Surg. 1982 Jun;69 (Suppl):S27–S28. doi: 10.1002/bjs.1800691310. [DOI] [PubMed] [Google Scholar]
  8. Intaglietta M., Silverman N. R., Tompkins W. R. Capillary flow velocity measurements in vivo and in situ by television methods. Microvasc Res. 1975 Sep;10(2):165–179. doi: 10.1016/0026-2862(75)90004-7. [DOI] [PubMed] [Google Scholar]
  9. Jacobs M. J., Beckers R. C., Jörning P. J., Slaaf D. W., Reneman R. S. Microcirculatory haemodynamics before and after vascular surgery in severe limb ischaemia--the relation to post-operative oedema formation. Eur J Vasc Surg. 1990 Oct;4(5):525–529. doi: 10.1016/s0950-821x(05)80796-0. [DOI] [PubMed] [Google Scholar]
  10. Jacobs M. J., Breslau P. J., Slaaf D. W., Reneman R. S., Lemmens J. A. Nomenclature of Raynaud's phenomenon: a capillary microscopic and hemorheologic study. Surgery. 1987 Feb;101(2):136–145. [PubMed] [Google Scholar]
  11. Jacobs M. J., Jörning P. J., Beckers R. C., Ubbink D. T., van Kleef M., Slaaf D. W., Reneman R. S. Foot salvage and improvement of microvascular blood flow as a result of epidural spinal cord electrical stimulation. J Vasc Surg. 1990 Sep;12(3):354–360. [PubMed] [Google Scholar]
  12. Jacobs M. J., Jörning P. J., Van Rhede van der Kloot E. J., Kitslaar P. J., Lemmens H. A., Slaaf D. W., Reneman R. S. Plasmapheresis in Raynaud's phenomenon in systemic sclerosis: a microcirculatory study. Int J Microcirc Clin Exp. 1991 Feb;10(1):1–11. [PubMed] [Google Scholar]
  13. Jünger M., Frey-Schnewlin G., Bollinger A. Microvascular flow distribution and transcapillary diffusion at the forefoot in patients with peripheral ischemia. Int J Microcirc Clin Exp. 1989 Feb;8(1):3–24. [PubMed] [Google Scholar]
  14. Maricq H. R., LeRoy E. C., D'Angelo W. A., Medsger T. A., Jr, Rodnan G. P., Sharp G. C., Wolfe J. F. Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders. Arthritis Rheum. 1980 Feb;23(2):183–189. doi: 10.1002/art.1780230208. [DOI] [PubMed] [Google Scholar]
  15. Maricq H. R., Spencer-Green G., LeRoy E. C. Skin capillary abnormalities as indicators of organ involvement in scleroderma (systemic sclerosis), Raynaud's syndrome and dermatomyositis. Am J Med. 1976 Dec;61(6):862–870. doi: 10.1016/0002-9343(76)90410-1. [DOI] [PubMed] [Google Scholar]
  16. SIMEONE F. A., HUSNI E. A. The hyperemia of reconstructive arterial surgery. Ann Surg. 1959 Oct;150:575–585. doi: 10.1097/00000658-195910000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Tyml K., Ellis C. G. Evaluation of the flying spot technique as a television method for measuring red cell velocity in microvessels. Int J Microcirc Clin Exp. 1982;1(2):145–155. [PubMed] [Google Scholar]
  18. Ubbink D. T., Jacobs M. J., Tangelder G. J., Slaaf D. W., Reneman R. S. Posturally induced microvascular constriction in patients with different stages of leg ischaemia: effect of local skin heating. Clin Sci (Lond) 1991 Jul;81(1):43–49. doi: 10.1042/cs0810043. [DOI] [PubMed] [Google Scholar]

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