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. 1983 Sep 24;11(18):6331–6339. doi: 10.1093/nar/11.18.6331

Chromosomal localization of the human c-fms oncogene.

J Groffen, N Heisterkamp, N Spurr, S Dana, J J Wasmuth, J R Stephenson
PMCID: PMC326376  PMID: 6684766

Abstract

A molecular probe was prepared with specificity for the human cellular homologue of transforming sequences represented within the McDonough strain of feline sarcoma virus (v-fms). By analysis of a series of mouse-human somatic cell hybrids containing variable complements of human chromosomes it was possible to assign this human oncogene, designated c-fms, to chromosome 5. Regional localization of c-fms to band q34 on chromosome 5 was accomplished by analysis of Chinese hamster-human cell hybrids containing as their only human components, terminal and interstitial deleted forms of chromosome 5. The localization of c-fms to chromosome 5 (q34) is of interest in view of reports of a specific, apparently interstitial, deletion involving approximately two thirds of the q arm of chromosome 5 in acute myelogenous leukemia cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbacid M., Lauver A. V., Devare S. G. Biochemical and immunological characterization of polyproteins coded for by the McDonough, Gardner-Arnstein, and Snyder-Theilen strains of feline sarcoma virus. J Virol. 1980 Jan;33(1):196–207. doi: 10.1128/jvi.33.1.196-207.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bishop J. M. Retroviruses and cancer genes. Adv Cancer Res. 1982;37:1–32. doi: 10.1016/s0065-230x(08)60880-5. [DOI] [PubMed] [Google Scholar]
  3. Chang E. H., Furth M. E., Scolnick E. M., Lowy D. R. Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus. Nature. 1982 Jun 10;297(5866):479–483. doi: 10.1038/297479a0. [DOI] [PubMed] [Google Scholar]
  4. Dalla-Favera R., Bregni M., Erikson J., Patterson D., Gallo R. C., Croce C. M. Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A. 1982 Dec;79(24):7824–7827. doi: 10.1073/pnas.79.24.7824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dalla-Favera R., Franchini G., Martinotti S., Wong-Staal F., Gallo R. C., Croce C. M. Chromosomal assignment of the human homologues of feline sarcoma virus and avian myeloblastosis virus onc genes. Proc Natl Acad Sci U S A. 1982 Aug;79(15):4714–4717. doi: 10.1073/pnas.79.15.4714. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dalla-Favera R., Gallo R. C., Giallongo A., Croce C. M. Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene. Science. 1982 Nov 12;218(4573):686–688. doi: 10.1126/science.6291150. [DOI] [PubMed] [Google Scholar]
  7. Dana S., Wasmuth J. J. Linkage of the leuS, emtB, and chr genes on chromosome 5 in humans and expression of human genes encoding protein synthetic components in human--Chinese hamster hybrids. Somatic Cell Genet. 1982 Mar;8(2):245–264. doi: 10.1007/BF01538680. [DOI] [PubMed] [Google Scholar]
  8. Dana S., Wasmuth J. J. Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5. Mol Cell Biol. 1982 Oct;2(10):1220–1228. doi: 10.1128/mcb.2.10.1220. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Der C. J., Krontiris T. G., Cooper G. M. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci U S A. 1982 Jun;79(11):3637–3640. doi: 10.1073/pnas.79.11.3637. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Donner L., Fedele L. A., Garon C. F., Anderson S. J., Sherr C. J. McDonough feline sarcoma virus: characterization of the molecularly cloned provirus and its feline oncogene (v-fms). J Virol. 1982 Feb;41(2):489–500. doi: 10.1128/jvi.41.2.489-500.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Groffen J., Heisterkamp N., Grosveld F., Van de Ven W., Stephenson J. R. Isolation of human oncogene sequences (v-fes homolog) from a cosmid library. Science. 1982 Jun 4;216(4550):1136–1138. doi: 10.1126/science.6281890. [DOI] [PubMed] [Google Scholar]
  12. Groffen J., Heisterkamp N., Stephenson J. R., van Kessel A. G., de Klein A., Grosveld G., Bootsma D. c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia. J Exp Med. 1983 Jul 1;158(1):9–15. doi: 10.1084/jem.158.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Heisterkamp N., Groffen J., Stephenson J. R. Isolation of v-fms and its human cellular homolog. Virology. 1983 Apr 15;126(1):248–258. doi: 10.1016/0042-6822(83)90476-2. [DOI] [PubMed] [Google Scholar]
  14. Heisterkamp N., Groffen J., Stephenson J. R., Spurr N. K., Goodfellow P. N., Solomon E., Carritt B., Bodmer W. F. Chromosomal localization of human cellular homologues of two viral oncogenes. Nature. 1982 Oct 21;299(5885):747–749. doi: 10.1038/299747a0. [DOI] [PubMed] [Google Scholar]
  15. Hobart M. J., Rabbitts T. H., Goodfellow P. N., Solomon E., Chambers S., Spurr N., Povey S. Immunoglobulin heavy chain genes in humans are located on chromosome. Ann Hum Genet. 1981 Oct;45(Pt 4):331–335. doi: 10.1111/j.1469-1809.1981.tb00346.x. [DOI] [PubMed] [Google Scholar]
  16. McBride O. W., Swan D. C., Santos E., Barbacid M., Tronick S. R., Aaronson S. A. Localization of the normal allele of T24 human bladder carcinoma oncogene to chromosome 11. Nature. 1982 Dec 23;300(5894):773–774. doi: 10.1038/300773a0. [DOI] [PubMed] [Google Scholar]
  17. Nabholz M., Miggiano V., Bodmer W. Genetic analysis with human--mouse somatic cell hybrids. Nature. 1969 Jul 26;223(5204):358–363. doi: 10.1038/223358a0. [DOI] [PubMed] [Google Scholar]
  18. Neel B. G., Jhanwar S. C., Chaganti R. S., Hayward W. S. Two human c-onc genes are located on the long arm of chromosome 8. Proc Natl Acad Sci U S A. 1982 Dec;79(24):7842–7846. doi: 10.1073/pnas.79.24.7842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Parada L. F., Tabin C. J., Shih C., Weinberg R. A. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature. 1982 Jun 10;297(5866):474–478. doi: 10.1038/297474a0. [DOI] [PubMed] [Google Scholar]
  20. Povey S., Jeremiah S. J., Barker R. F., Hopkinson D. A., Robson E. B., Cook P. J., Solomon E., Bobrow M., Carritt B., Buckton K. E. Assignment of the human locus determining phosphoglycolate phosphatase (PGP) to chromosome 16. Ann Hum Genet. 1980 Jan;43(3):241–248. doi: 10.1111/j.1469-1809.1980.tb01557.x. [DOI] [PubMed] [Google Scholar]
  21. Prakash K., McBride O. W., Swan D. C., Devare S. G., Tronick S. R., Aaronson S. A. Molecular cloning and chromosomal mapping of a human locus related to the transforming gene of Moloney murine sarcoma virus. Proc Natl Acad Sci U S A. 1982 Sep;79(17):5210–5214. doi: 10.1073/pnas.79.17.5210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Reynolds F. H., Jr, Van de Ven W. J., Blomberg J., Stephenson J. R. Differences in mechanisms of transformation by independent feline sarcoma virus isolates. J Virol. 1981 Jun;38(3):1084–1089. doi: 10.1128/jvi.38.3.1084-1089.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Santos E., Tronick S. R., Aaronson S. A., Pulciani S., Barbacid M. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes. Nature. 1982 Jul 22;298(5872):343–347. doi: 10.1038/298343a0. [DOI] [PubMed] [Google Scholar]
  24. Sokal G., Michaux J. L., Van Den Berghe H., Cordier A., Rodhain J., Ferrant A., Moriau M., De Bruyere M., Sonnet J. A new hematologic syndrome with a distinct karyotype: the 5 q--chromosome. Blood. 1975 Oct;46(4):519–533. [PubMed] [Google Scholar]
  25. Solomon E., Bobrow M., Goodfellow P. N., Bodmer W. F., Swallow D. M., Povey S., Noël B. Human gene mapping using an X/autosome translocation. Somatic Cell Genet. 1976 Mar;2(2):125–140. doi: 10.1007/BF01542626. [DOI] [PubMed] [Google Scholar]
  26. Solomon E., Bobrow M., Goodfellow P. N., Bodmer W. F., Swallow D. M., Povey S., Noël B. Human gene mapping using an X/autosome translocation. Somatic Cell Genet. 1976 Mar;2(2):125–140. doi: 10.1007/BF01542626. [DOI] [PubMed] [Google Scholar]
  27. Southern E. M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 1975 Nov 5;98(3):503–517. doi: 10.1016/s0022-2836(75)80083-0. [DOI] [PubMed] [Google Scholar]
  28. Swallow D. M., Solomon E., Pajunen L. Immunochemical analysis of the N-acetyl hexosaminidases in human-mouse hybrids made using a double selective system. Cytogenet Cell Genet. 1977;18(3):136–148. doi: 10.1159/000130758. [DOI] [PubMed] [Google Scholar]
  29. Swan D. C., McBride O. W., Robbins K. C., Keithley D. A., Reddy E. P., Aaronson S. A. Chromosomal mapping of the simian sarcoma virus onc gene analogue in human cells. Proc Natl Acad Sci U S A. 1982 Aug;79(15):4691–4695. doi: 10.1073/pnas.79.15.4691. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Taub R., Kirsch I., Morton C., Lenoir G., Swan D., Tronick S., Aaronson S., Leder P. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci U S A. 1982 Dec;79(24):7837–7841. doi: 10.1073/pnas.79.24.7837. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Van de Ven W. J., Reynolds F. H., Jr, Nalewaik R. P., Stephenson J. R. Characterization of a 170,000-dalton polyprotein encoded by the McDonough strain of feline sarcoma virus. J Virol. 1980 Jul;35(1):165–175. doi: 10.1128/jvi.35.1.165-175.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Van den Berghe H., Cassiman J. J., David G., Fryns J. P., Michaux J. L., Sokal G. Distinct haematological disorder with deletion of long arm of no. 5 chromosome. Nature. 1974 Oct 4;251(5474):437–438. doi: 10.1038/251437a0. [DOI] [PubMed] [Google Scholar]
  33. Van den Berghe H., David G., Michaux J. L., Sokal G., Verwilghen R. 5q-Acute myelogenous leukemia. Blood. 1976 Oct;48(4):624–626. [PubMed] [Google Scholar]
  34. Varmus H. E. Form and function of retroviral proviruses. Science. 1982 May 21;216(4548):812–820. doi: 10.1126/science.6177038. [DOI] [PubMed] [Google Scholar]
  35. Whitehead A. S., Solomon E., Chambers S., Bodmer W. F., Povey S., Fey G. Assignment of the structural gene for the third component of human complement to chromosome 19. Proc Natl Acad Sci U S A. 1982 Aug;79(16):5021–5025. doi: 10.1073/pnas.79.16.5021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. de Klein A., van Kessel A. G., Grosveld G., Bartram C. R., Hagemeijer A., Bootsma D., Spurr N. K., Heisterkamp N., Groffen J., Stephenson J. R. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1982 Dec 23;300(5894):765–767. doi: 10.1038/300765a0. [DOI] [PubMed] [Google Scholar]

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