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. 1983 Oct 25;11(20):7181–7190. doi: 10.1093/nar/11.20.7181

Molecular cloning and nucleotide sequence of a human renin cDNA fragment.

F Soubrier, J J Panthier, P Corvol, F Rougeon
PMCID: PMC326449  PMID: 6138751

Abstract

We have studied human renin messenger RNA by hybridization with the mouse submaxillary gland (SMG) renin cDNA probe. The human kidney messenger RNA is about 1.6 kilobase (kb) long, similarly to the mouse SMG renin mRNA. A kidney renin cDNA clone of 1.1 kb length was obtained. A comparison of nucleotide sequences of mouse and human cDNA clones reveals conservation of residues involved in catalytic mechanisms and a potential glycosylation site. The human renin molecular probe allowed us to study renin expression in human chorionic tissue. The chorionic and kidney renin messenger RNAs are similar in length. The Southern blot analysis reveals the presence of a single renin gene in human DNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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