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. Author manuscript; available in PMC: 2012 Mar 2.
Published in final edited form as: Epilepsia. 2011 Mar 2;52(3):e12–e15. doi: 10.1111/j.1528-1167.2011.02988.x

Figure.

Figure

Single injection of neuraminidase decreased frequency of hippocampal IIS in pilocarpine model of epilepsy. (A) IIS recording from CA1 region of hippocampus from IP pilocarpine treated rat before (upper panel) and 3 days after (lower panel) of intrahippocampal neuraminidase (NEU) injection. IIS marked with squares shown in expanded scales in the right panel. (B) Summary plot shows effect of NEU on IIS frequency recorded from IP (n = 12) and IH (n = 16) pilocarpine-treated rats. All data and statistics are shown relatively to the mean control obtained from three day recordings before NEU injection. Controls were pooled from two hours recordings obtained for each rat three times during the week before NEU injection. Day 0 to Week 4 columns represent relative decreases in IIS frequency over the first day and 4 subsequent weeks post-NEU injection. All columns are mean±SD. Statistics were done using Wilcoxon matched-pairs signed rank test, *p < 0.05, ** p < 0.01 versus control.