Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice

Original citation: J. Clin. Invest. 2012;122(1):70–79. doi:10.1172/JCI43713.

Citation for this erratum: J. Clin. Invest. 2012;122(2):783. doi:10.1172/JCI62827.

During the preparation of this manuscript, errors were inadvertently introduced into the legends for Figures 1, 2, and 3. The correct sections of the legends appear below.

Figure 1: (B) Quantification of total atherosclerotic plaque area within the aortic root of Il1r1^+/+Apoe^–/– and Il1r1^–/–Apoe^–/– mice at 150-μm intervals from the aortic valve attachment site (P < 0.001 for difference between genotypes by Scheirer-Ray-Hare test). n = 13, Il1r1^+/+Apoe^–/–; n = 12, Il1r1^–/–Apoe^–/–. Data represent mean ± SEM.

Figure 2: L-1R1 deficiency reduces compensatory outward remodeling of atherosclerotic brachiocephalic arteries. (A) Movat staining of representative brachiocephalic arteries of Il1r1^–/–Apoe^–/– and Il1r1^+/+Apoe^–/– mice. Scale bars: 200 μm. (B–D) Atherosclerotic plaque area (B), vessel area within the IEL (P < 0.001 for difference between genotypes by 2-way ANOVA) (C), and lumen area (P < 0.001 for difference between genotypes by 2-way ANOVA after square root transformation) (D) at multiple locations along the brachiocephalic arteries of Il1r1^–/–Apoe^–/– and Il1r1^+/+Apoe^–/– mice. n = 14, Il1r1^+/+Apoe^–/–; n = 12, Il1r1^–/–Apoe^–/–. Data in B–D represent mean ± SEM.

Figure 3: (F–J) Quantification of (F) plaque collagen content based on picrosirius red staining, P < 0.001 for difference of genotypes by 2-way ANOVA, (G) plaque SMC coverage based on SM α-actin staining, P < 0.001 for difference of genotypes by the Scheirer-Ray-Hare test, (H) total plaque SMC content based on SM α-actin staining, P < 0.001 for difference of genotypes by the Scheirer-Ray-Hare test, (I) plaque macrophage content based on Mac2 staining, P = 0.01 for difference of genotypes by 2-way ANOVA after log transformation, and (J) the percentage of brachiocephalic arteries exhibiting intraplaque hemorrhage based on Movat and TER-119 staining, **P < 0.01 by Fisher’s exact test.

The JCI regrets the error.