Table 2.
Summary table of the known relationships between eicosanoids and HIV in the CNS.
| Exposure to | Type of cells or mode of exposure | Species | Product | Effect | Mediated by | Citation |
|---|---|---|---|---|---|---|
| gp120 | intracerebral injection | rat | PGE2 | neuronal apoptosis | IL-1β | 159, 160 |
| gp120 | intracerebral injection | rat | PGE2 | neuronal apoptosis | N/A | 161 |
| gp120 | astrocytes | human | PGE2 | neurotoxicity | N/A | 162 |
| gp120 | neurons | human | N/A | neurotoxicity | 5-LO/PGHS | 172 |
| Tat | intracerebral injection | mouse | COX-2 | Neuroinflammation | NFKb | 166 |
| Tat | tail vein injection | mouse | COX-2 | BBB disruption | N/A | 165 |
| LTs | microglia | human | N/A | HIV inhibition | PKC | unpublished |
| HIV-1 | endothelial cells/macrophages | human | COX-2 | Neuroinflammation | IL-1b | 150 |
N/A: Non available data
PGHS: prostaglandin H synthase