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. 1982 Dec 20;10(24):7965–7976. doi: 10.1093/nar/10.24.7965

Transcriptional 'enhancers' from SV40 and polyoma virus show a cell type preference.

J de Villiers, L Olson, C Tyndall, W Schaffner
PMCID: PMC327063  PMID: 6298703

Abstract

Transcriptional "enhancers" have been identified in both the monkey virus SV40 and in the mouse polyoma virus. Here we report that these enhancers show a cell type preference. This was done, (i) by assaying for T antigen expression and viral DNA replication of polyoma DNA which contains its own enhancer or the enhancer of SV40 virus, and (ii) by linking either of the two enhancer elements to the rabbit beta 1-globin gene and measuring transient globin expression in mouse and primate cells. The results were consistent in all the assays: In mouse cells the polyoma enhancer is slightly more effective than the SV40 enhancer. However, in primate cells the SV40 enhancer induces a four to six fold higher level of gene expression than does the polyoma enhancer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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