Sir,
This reply is in response to the letter I received.[1] Some points worth mentioning are as follows:
We have not reported microdeletions in 51.6% of azoospermic and 52.6% of severe oligozoospermic men as they claim. Instead, we have reported 52% (26 persons) of patients (including azospermics and oligospermics men) with microdeletions. Of these 26 patients with microdeletions, 16 (61.5%) azoospermics and 10 (38.5%) oligozoospermics were recorded.[2]
Only 3 persons (patient number 11, 30, and 34) had deletion in sY254. Of these 3 patients, 1 (number 34) had deletion with six other STS markers including sY255. Therefore, only 2 patients had deletion in sY254 and normal with sY255. What our colleagues claim in their letter is true, but the reason behind this could be polymorphism or mistake in reading or performing the test for those 2 patients.
REFERENCES
- 1.Saliminejad K, Khorshid HRK. Discrepancy in the results of Y chromosome microdeletions in an Iranian population. J Hum Reprod Sci. 2011;4:157. doi: 10.4103/0974-1208.92295. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Malekasgar AM, Mombaini H. Screening of Y chromosome microdeletions in Iranian infertile males. J Hum Reprod Sci. 2008;1:2–9. doi: 10.4103/0974-1208.38973. [DOI] [PMC free article] [PubMed] [Google Scholar]