Table 2.
Pharmacokinetic parameters after oral DAC versus oral THU-DAC in female mice (mean values from 3 mice at each time point in each group)
| Group | THU-DAC 0.1 | THU-DAC 0.2 | THU-DAC 0.4 | DAC 0.4 only |
|---|---|---|---|---|
| DAC dose, mg/kg | 0.1 | 0.2 | 0.4 | 0.4 |
| THU dose, mg/kg | 167 | 167 | 167 | 0 |
| AUCt, min/μM | 17.90 | 35.64 | 76.24 | 8.45 |
| Cmax, μM | 0.138 | 0.338 | 0.617 | 0.251 |
| AUCt coefficient of variation | 0.15 | 0.24 |
*
Drugs were administered 2 times per week for 3 weeks and blood for pharmacokinetic analysis was collected on the last day of dosing (day 16).