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. 1979 Mar;6(3):1177–1187. doi: 10.1093/nar/6.3.1177

Photosensitized formation of thymine dimers in DNA by tyramine, tyrosine and tyrosine-containing peptides.

M Kaneko, A Matsuyama, C Nagata
PMCID: PMC327762  PMID: 375196

Abstract

The formation of Thy-Thy in DNA in the presence of tyramine, tyrosine and tyrosine-containing peptides such as Lys-Tyr and Lys-Tyr-Lys was studied with monochromatic UV irradiation. The formation of Thy-Thy by UV irradiation was enhanced in the presence of these compounds. The action spectrum of the photosensitization has a peak near 280 nm corresponding to the absorption spectrum of tyrosine. The triplet quencher reduced the sensitization substantially. The sensitization in native DNA was more than six times larger than that in denatured DNA. increasing the concentration of salts suppressed the sensitization. The nature of the interaction between DNA and the sensitizer is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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