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. 1979 Apr;6(4):1695–1708. doi: 10.1093/nar/6.4.1695

Fluoride ion catalyzed alkylation of purines, pyrimidines, nucleosides and nucleotides using alky halides.

K K Ogilvie, S L Beaucage, M F Gillen, D Entwistle, M Quilliam
PMCID: PMC327801  PMID: 450712

Abstract

Alkyl halides react rapidly with purines and pyrimidines in the presence of fluoride ion. Alkylation of thymidine leads to novel dimeric nucleoside derivatives bridged through N3. Alkylation of thymidine mono and dinucleotides leads to alkylation at the base (N3) as well as diester and triester formation at the phosphate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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